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Prolactinoma The pituitary gland increases in size by 50–70% in pregnancy due to normal lactotroph hyperplasia, which in rare cases causes symptoms in pregnancy The presence of an adenoma, called a prolactinoma, in the pituitary gland will further increase its size and cause symptoms.
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This adenoma, or cyst, increases the production of prolactin, which is the hormone that initiates lactation. There are two types of adenoma: Microadenoma: accounts for 90% of cases in pregnancy. They are <10 mm in diameter rarely grow significantly regressing spontaneously.
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Macroadenoma: accounts for 10% of cases in pregnancy.
They are >10 mm in diameter more likely to expand and cause symptoms of headache and visual disturbance. progress to pituitary apoplexy or diabetes insipidus . With both types of adenoma there is a risk of infertility and treatment is with
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dopamine agonists, which cause side-effects of :
1-nausea, vomiting 2- postural hypotension, 3- constipation 4-nasal congestion 5- Raynaud's phenomenon
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Pre-conception care ; -management depends upon the size of the adenoma which might involve a trial of discontinuing the dopamine agonist or changing to bromocriptine. - In some cases, surgery might be afempted prior to conception to reduce the bulk size of the adenoma
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-Once pregnant, the woman should be referred to a specialist unit as this is a high-risk pregnancy.
- Antenatal care, however, can be shared with the community midwife and medical/obstetric team. -At the initial visit the midwife should take particular note of past surgery and current medication when undertaking the woman's history. - At each subsequent visit the woman should be asked about headache and visual symptoms.
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-It is the medical team who will determine the type and dose of dopamine agonist and perform monthly visual perimetry to detect early signs of compression on the optic chiasma -If there are indications of adenoma expansion, a magnetic resonance imaging (MRI) scan should be performed urgently and bromocriptine commenced. -In most cases the intrapartum care can be facilitated by the midwife, however if the adenoma is expanding the woman is likely to have a preterm induction of labour. -The obstetric team may advise an elective instrumental birth to avoid a rise in intracranial pressure during the second stage of labour
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-In the postnatal period the woman is advised to report any symptoms
-In the postnatal period the woman is advised to report any symptoms. An MRI scan might be ordered by the medical team and prolactin levels measured aher 3 weeks, by which time the values should have returned to their pre-pregnancy levels. -Follow-up appointments should be made with the specialist medical team who will evaluate the symptoms when determining the re-commencement of pre-pregnancy treatment with dopamine agonists.
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The midwife should consult with the doctor and pharmacist for suitable alternative medication if the woman wishes to breastfeed her baby as dopamine agonists are usually contraindicated. - Furthermore, the woman will require specialist contraception advice as oestrogen contained within the oral contraceptive pill might further increase the size of the adenoma and consequently is contraindicated
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