1. EVOLUT R, Next Generation, and Future
Rhonda Robb
Medtronic, plc

2. Disclosure: Rhonda Robb is an employee of Medtronic, plc

3. Self Expanding Program Milestones
10 years since first commercial approval (CE mark)
Launched in more than 80 countries
>160,000 patients treated
>12,000 patients enrolled in MDT sponsored clinical trials (does not include country sponsored registries)
40+ publications in peer reviewed journals
SURTAVI Intermediate Risk enrollment complete
LBCT Presentation at ACC 3/17
Low Risk Global Trial enrolling

4. Program Milestones ENCOURAGING RESULTS TO 3 YEARS, FOLLOWING TO 10 YEARS

5. Program Milestones TVT DATA MATCHES US PIVOTAL DATA

6. Program Milestones IMPROVED OUTCOMES WITH EVOLUT R

7. Medtronic Transcatheter Valve Design
Evolut r builds on the proven foundation of the corevalve platform
CoreValve™
Evolut™ R
Evolut™ R Design Goals
Low Delivery Profile
Unsurpassed Hemodynamics
Improved Annular Sealing with Frame Conformability
Consistent Radial Force
Optimized Oversizing
Extended Skirt
Supra-Annular Valve
Porcine Pericardial Tissue Cell Size Enables Coronary Access
Self-Expanding Frame
Pericardial Skirt

8. Patient Annulus Diameter (mm)
EVOLUT R
ABILITY TO TREAT BROADEST ANNULUS RANGE 18 19 20 21 22 23 24 25 26 27 28 29 30
Patient Annulus Diameter (mm)

9. EnVeo R Delivery Catheter System
Control during deployment ability to recapture and reposition the valve
Lowest TRUE Profile 14Fr/16Fr-equivalent Vessel Access ≥ 5.0 mm (23, 26, 29 TAV) ≥ 5.5 mm (34 TAV)
Accurate Positioning 1:1 response provides immediate feedback between deployment knob and movement of the capsule
Recapture and Reposition Provides option to recapture and reposition for accurate placement

10. Exceptional Hemodynamics
Supra-annular valve design maximizes orifice area

11. Eliminates Open Spaces Between Struts
Evolut PRO
Enhanced sealing with proven platform performance
Evolut™ R
Evolut™ PRO
Pericardial Wrap Increases Surface Contact Area 8X for Acute Performance and Enhanced Healing
Supra-Annular Valve
Porcine Pericardial Tissue Cell Size Enables Coronary Access
Self-Expanding Frame
Pericardial Skirt
Skirt Height
13 mm
Eliminates Open Spaces Between Struts
Sealing can occur at multiple levels; including above and below calcification with a self-expanding frame
Investigational device and not approved for sale

12. EnVeo PRO SEAMLESS tracking Especially in Tortuous Anatomies
Next Generation delivery system
SEAMLESS tracking Especially in Tortuous Anatomies
FLEXIBLE CAPSULE
Investigational device and not approved for sale

13. Future Medtronic TAVR Programs
Continuously building upon a proven, superior platform
Evolut NG
Horizon
Steerable
Novel concentric deployment
Ultra low profile
Complete Control
Shorter frame
Visualization
Superior Hemodynamics
Complete Sealing
Investigational device and not approved for sale

14. Self Expanding is a Platform for Expansion
Developing novel valves for specific disease states with patient anatomical and clinical needs in mind
AORTIC
PULMONIC
MITRAL
Investigational devices and not approved for sale

15. Conclusions
Clear evidence of patient benefit in Extreme/High Risk Patients
Program advancements have further improved outcomes
New patient populations are under study
Continued self expanding platform innovations in TAVI and novel designs for congenital and mitral

16. Thank You We Truly Appreciate the Collaboration to Advance the Field