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Second-generation percutaneous bioprosthetic valve: A short-term study in sheep  Dusan Pavcnik, MD, PhD, John Kaufman, MD, Barry Uchida, BS, Luiz Correa,

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Presentation on theme: "Second-generation percutaneous bioprosthetic valve: A short-term study in sheep  Dusan Pavcnik, MD, PhD, John Kaufman, MD, Barry Uchida, BS, Luiz Correa,"— Presentation transcript:

1 Second-generation percutaneous bioprosthetic valve: A short-term study in sheep 
Dusan Pavcnik, MD, PhD, John Kaufman, MD, Barry Uchida, BS, Luiz Correa, MD, Takao Hiraki, MD, Seong Chang Kyu, MD, Frederick S. Keller, MD, Josef Rosch, MD,  Journal of Vascular Surgery  Volume 40, Issue 6, Pages (December 2004) DOI: /j.jvs Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Second-generation bioprosthetic venous valve. A, Stainless steel Z-stent is attached to apex of original square stent valve. Z-stent has barbs at its upper bends. B, Nonrestrained nitinol double-stent bioprosthetic venous valve with 4 barbs for maximal vein diameter of 12 to 14 mm. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Function of double-stent bioprosthetic venous valve placed in sheep jugular vein 11 mm in diameter at 6-week follow-up. A, Jugular venogram with injection above valve demonstrates valve patency. B, High-volume injection of contrast medium below valve does not reveal any reflux, and demonstrates valve closure. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Specimen and histologic analysis of 10-mm to 12-mm double-stent bioprosthetic venous valve placed in sheep jugular vein 11 mm in diameter at 6-week follow-up. A, Axial view from above shows incorporation of valve into vein wall. B, Longitudinally cut specimen shows smooth, almost complete incorporation of the double-stent bioprosthetic venous valve into vein wall. C, Longitudinal microscopic view of small intestinal submucosa leaflet (original mgnification ×2). D, Magnified view of early remodeled small intestinal submucosa leaflet reveals endothelial and other host cells, as previously described5,8 (hematoxylin-eosin stain; original magnification ×200). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

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