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Biochemistry Free For All

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Presentation on theme: "Biochemistry Free For All"— Presentation transcript:

1 Biochemistry Free For All
Membrane Transport Biochemistry Free For All

2 Chemical and Electrical Potential Across a Lipid Bilayer Barrier

3 Osmotic Pressure Across a Semipermeable Barrier

4

5 Types of Membrane Proteins

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8 Three Types of Membrane Protein Ports
Symport (Synport) Uniport Antiport

9 No Net Change in Charge Net Change in Charge

10 Ion Channels

11 Ion Channel Features 1. General Structure 2. Opening 3. Filter 4. Effective Opening Size 5. Door

12 Closed Open Potassium Channel

13 Potassium Channel - Top-down View

14 Hydration Shell

15

16 Cellular Transport Types
Passive - Purely Diffusion Driven, Follows Concentration Gradient Facilitated - Protein Guided, Follows Concentration Gradient Active - Protein Guided, Energy Required to Move at Least One Molecule Against Concentration Gradient

17 Passive Transport - Purely Diffusion Driven

18 Ion Channels vs Transporters

19 Facilitated Diffusion

20 Active Transport

21 Sodium-Potassium ATPase
Higher K+ inside Higher Na+ outside Sodium-Potassium ATPase

22 Sodium/Glucose Symport
Secondary Energy Source Sodium-Glucose Pump Sodium/Glucose Symport

23 Lactose/Proton Symport
Lactose Permease Lactose/Proton Symport

24 Secondary Energy Source - Protons
Lactose Permease Secondary Energy Source - Protons

25 Voltage Change

26 Nerve Cell Transmission
1. Stimulus 2. Opening of Na+ gates 3. Na+ diffuses into cell 4. Voltage change causes K+ gates to open 5. K+ diffuses out of cell 6. All gates close 7. Wave of voltage changes moves down cell 8. Neurotransmitters move signal across cells 9. Na+ K+ ATPase restores gradients in originating cell

27 Stimulus, Na+ gates open
K+ gates open Action Potential Stimulus, Na+ gates open Na+K+ ATPase acts

28 Transmission of signal from one cell to another
Gates Gates Wave of Na+ in, K+ out Transmission of signal from one cell to another

29

30 Bind Voltage Gated Na+ Channels
Tetrodotoxin From Puffer Fish Bind Voltage Gated Na+ Channels

31 Shellfish Toxin From Algal Blooms Sodium Channel Blocker
Saxitoxin Shellfish Toxin From Algal Blooms Sodium Channel Blocker


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