1. Organ-on-a-Chip
By Borui Li and Team

2. Contents What is an Organ-on-a-Chip? How is it built?
Example: Lung-on-a-Chip
Pros and Cons
The Future of Organ-on-a-Chip
Industry

3. What is an Organ-on-a-chip?
Microfluidic chip
Contains tissue cultures
Simulates physiological function

4. Structure PDMS (Poly-dimethylsiloxane) Simple Complex 1 Chamber
Figure 2 Bhatia et al. 2014
Simple
1 Chamber
Complex
2 Chambers
Figure 4C Bhatia et al. 2014
Figure 1 Bhatia et al. 2014
PDSM - Poly-dimethylsiloxane
Main material in microfluidic chip
Photolithographic etching (fabrication)
Figure 2
A - One chamber, 1 tissue type
B - One chamber, 2 tissue types
C -

5. Experiments with Organ-on-a-Chip
Construction
Drug screen modeling
Disease experiments c
Figure 6A An et al. 2015
Just building the different types of chips
Testing differences between drug screening on animal models, cell cultures, and chip.

6. LUNG-ON-A-CHIP Lung on a chip is a complex structure.
Retrieved from the Wyss Institute for Biologically Inspired Engineering at Harvard University
Lung on a chip is a complex structure.

7. How it works: Vacuum channels Air and blood flow
Replicating bacterial infections
Adapted from the Wyss Institute for Biologically Inspired Engineering at Harvard University

8. How it works: Vacuum channels Air and blood flow
Replicating bacterial infections
Retrieved from the Wyss Institute for Biologically Inspired Engineering at Harvard University

9. What can we learn from this?
Effect of diseases
Potential new treatments
Effects of environmental toxins and air pollutants
Retrieved from the Wyss Institute for Biologically Inspired Engineering at Harvard University

10. Three Models of Clinical Drug Testing

11. Future
Human on a chip
Plug-and-Chug instruments and analyzing software
Individualized medicine based on your stem cells

12. Industry Easily scalable Cosmetic industry Big Pharma
Rampant commercialization post 2020
Billions!
Business leaders like it because it is easily scalable, so once the R&D work is done, the prices can be brought down low enough to make millions of chips
Big Pharma would love this technology, as the chips bring down the cost of research and development down significantly. And in Pharmaceutical companies, R&D is usually the biggest expense.
And just to give an example, The cosmetic industry, like Proactive, L’oreal all would love to stop doing animal testing because it costs so much, and this technology would save so much money
Because ORC is still a new technology, the high R&D costs has restricted growth. However, according to one marketing firm, the industry is expected to go through rampant commercialization post 2020
This can be a billion dollar industry, so it’s a good idea to invest right now.

13. Summary What is an Organ-on-a-Chip How they are built and used
Lung-on-a-Chip
Pros and Cons
The Future of Organ-on-a-Chip
Industry

14. Questions?

15. Citations
Esch, E. W., Bahinski, A., & Huh, D. (2015). Organs-on-chips at the frontiers of drug discovery. Nature, 14,
"Living, Breathing Human Lung-on-a-chip: A Potential Drug-testing Alternative." Wyss Institute. 24 June Web. 29 Apr
Bhatia, S.N., and Ingber, D.E. (2014). Microfluidic Organs-on-chips. Nature Biotechnology, 32,
“Human Organs-on-Chips” Wyss Institute Web, 5 May. 2017
Conant, G., Lai, B.F.L., Lu, R.X.Z., Korolj, A., Wang, E.Y., and Radisic, M. (2017). High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model. Stem Cell Reviews and Reports, 1-12.
An, F., Qu, Y., Liu, X., Zhong, R., and Luo, Y. (2015). Organ-on-a-Chip: New Platform for Biological Analysis. Anal Chem Insights. 10:
"Organ-on-a-chip Market Global Industry Insights, Trends, Outlook, and Opportunity Analysis, " Home. Coherent Market Insights, 21 Mar Web. 06 May 2017.