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DNA Replication, Repair & Recombination

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Presentation on theme: "DNA Replication, Repair & Recombination"— Presentation transcript:

1 DNA Replication, Repair & Recombination
Biochemistry Free For All

2 Structure

3 Structure

4 One Strand of DNA Structure

5 Structure Introduction

6 Structure Introduction

7 DNA Structure

8 DNA Forms

9 Semi-Conservative Replication
Continuous Replication on Leading Strand Discontinuous Replication on Lagging Strand (Okazaki Fragments)

10 Leading and Lagging Strand DNA Replication
Leading Strand Lagging Strand

11 DNA Replication

12 DNA Replication

13 DNA Replication

14 DNA Polymerase I

15 DNA Polymerase I Structure

16 DNA Replication Proteins

17 Replication Fork

18 Beta Clamp DNA Top View Side View

19 Chemical Mechanism of Chain Elongation

20 Leading / Lagging Strand Replication

21 DNA Topoisomers

22 Topoisomerase Action

23 Topoisomers/Topoisomerases
L = T+W L = Linking Number T = Twists W = Writhes

24 Polymerase Chain Reaction

25 Polymerase Chain Reaction

26 Polymerase Chain Reaction

27 Polymerase Chain Reaction

28 Polymerase Chain Reaction

29 DNA Proof-reading

30 Prokaryotic vs Eukaryotic DNA Replication
Introduction

31 Chromosomes With Telomeres

32 Linear DNA Replication

33 Telomerase Action

34 Telomerase Action

35 Nucleotide Excision Repair
Bulky DNA Adduct

36 Nucleotide Excision Repair

37 Nucleotide Excision Repair

38 Nucleotide Excision Repair
Thymine Dimers

39 Nucleotide Excision Repair
Partial Strand Removal Thymine Dimer Repair

40 Base Excision Repair Cytosine Deamination Cytosine Uracil

41 Flipping out of base from helix Base Excision Repair

42 Uracil-N-Glycosylase Catalysis
Excision of Base Base Excision Repair Uracil-N-Glycosylase Catalysis

43 DNA Mismatch Repair Mismatch

44 DNA Mismatch Repair Unmethylated, recognizable Methylated,
unrecognizable

45 Measuring Mutation Ames Test

46 DNA Recombination

47 DNA Recombination Strand Invasion

48 Structure Introduction

49 DNA Recombination Holliday Junction

50 Recombination/Repair

51 RecA Recombination Repair in E. coli


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