1. Collaborative Initiative on FASD
Participating Site: The University of New Mexico
Principal Investigator - Philip A. May, Ph.D.
Piyadasa Kodituwakku, Ph.D.
Colleen Adnams, M.D.
Wendy Kalberg, M.A., CED
Alfredo Aragon, Ph.D.

2. Objectives
To adminsiter a neurobehavioral core test battery to children with confirmed prenatal alcohol exposure and controls from communities in South Africa and the Northern Plains, for combination with data collected at other international sites.
To test the radex model which hypothesizes that complex tasks at the top of the task hierarchy highly discriminate between children with FASD and controls.

3. New Mexico Site Progress Report
23 children tested to date
13 males and 10 females
16 Controls, 7 FASD

4. Progress Next clinics scheduled February, March, and April, 2006.
Will see additional affected and control children to meet our numbers of 25 affected children and 25 control children.
Alfredo Aragon, Ph.D. and Jason Blankenship, Ph.D. traveled to San Diego for quality assurance meeting.
Went well – following San Diego’s direction
David Buckley is the dedicated person for interface with Informatics Core at Indiana from New Mexico.
Plan to enter data for consortium use within the next 6 months

5. SA Accomplishments 2005/6
Sean September, MA, Psychometrist completed training and piloting the battery
Training videos sent to San Diego - in process of feedback
Bernice Castle, MA oversees day to day activities of this and intervention project
Phil May and Wendy Kalberg site visits
Testing in progress

6. Some Preliminary Data from SA
56 children tested
FASD = 34 (22 males; 12 females)
Non exposed controls = 22 (10 males; 12 females)
Mean age: FASD = 10 yr 5mths
Controls = 10yr 1 mth
All children from 10 schools in the same community

7. Data at FASD Diagnosis - SA
These 56 participants were recruited from a previous epidemiological study in 2002 (Wellington wave 3).
They are also participants in the intervention study, so we have supplemental dysmorphology, demographic, maternal and neurobehavioral data to that collected in the International Neuropsychological study.

8. Data Obtained at FASD Diagnosis
FASD n= 34
Mean (SD)
Control n=22
P value
Dysmorph. score
(4.38)
7.72 (4.42)
<0.001
Head
circumference
48.9 (1.69)
(1.30)
<.001
Behavior score
PBCL-36
8.59 (8.62)
2.04 (2.60)

9. International Neuropsychological Battery: Selected data
Leiter IQ Score
FASD: (SD = 12.6)
Control: (SD = 12.2)
* p = 0.002
* significant correlation with dysmorphology score, head cirumference at time of diagnosis

10. Visual Motor Integration
FASD n= 34
Mean mental age mths (SD)
Control n=22
P value
Beery Visual Motor Integration
91.9 (22.3)
(19.8)
.017
Beery Visual Perception
64.9 (13.6)
(12.5)
.001
Beery Motor Perform.
89.4 (15.2)
97.3 (20.7)
N/S

11. Edinburgh Handedness:
No difference in:
Edinburgh Handedness:
right handed: n = 55
Left handed: n = 1 (FASD)
Depression Scale
FASD = (SD 7.54)
Control = 7.00 (SD 3.74)

12. Achenbach Scales: Teacher’s Behavior Reports
DSM-4 Behaviors
FASD n= 34
Mean score (SD)
Control n=22
P value
Affect
2.96 (3.3)
(.91)
.001
Anxiety
1.96 (2.13)
(1.2)
.007
Somatic
0.57 (1.23)
0.14 (0.47)
N/S
Inattention
4.92 (3.49)
0.90 (0.12)
.000
Hyperactivity
(4.5)
1.09 (1.78)
.01
ADHD Total
8.61 (7.10)
2.00 (2.72)
Oppositional Def.
1.11 (1.96)
0.47 ( 1.07)
Conduct Disorder
2.69 (4.21)
0.43 (0.87)
.013

13. Berkley Sluggish Tempo (ADHD behaviors)
FASD n= 34
Mean (SD)
Control n=22
P value
Total Score
(11.16)
8.35 (6.82)
0.004