1. Decrease of Prefrontal Metabolism After Subthalamic Stimulation in Obsessive- Compulsive Disorder: A Positron Emission Tomography Study 
Florence Le Jeune, Marc Vérin, Karim N'Diaye, Dominique Drapier, Emmanuelle Leray, Sophie Tezenas Du Montcel, Nicolas Baup, Antoine Pelissolo, Mircea Polosan, Luc Mallet, Jérome Yelnik, Bertrand Devaux, Denys Fontaine, Isabelle Chereau, Aurélie Bourguignon, Julie Peron, Paul Sauleau, Sylvie Raoul, Etienne Garin, Marie-Odile Krebs, Nematollah Jaafari, Bruno Millet 
Biological Psychiatry 
Volume 68, Issue 11, Pages (December 2010)
DOI: /j.biopsych
Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

2. Figure 1
Design of positron emission tomography analysis in patients suffering from severe obsessive-compulsive disorder treated by subthalamic nucleus deep brain stimulation. CE, clinical evaluation; D, day; M, month.
Biological Psychiatry  , DOI: ( /j.biopsych )
Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

3. Figure 2
Significant increase in glucose metabolism in the right frontal middle gyrus (Brodmann's area 10) in Off-Stimulation obsessive-compulsive disorder patients compared with healthy control subjects (p < .005). Coronal views projected onto brain slices of a standard magnetic resonance imaging (x,y,z Talairach coordinates).
Biological Psychiatry  , DOI: ( /j.biopsych )
Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

4. Figure 3
Significant decrease in glucose metabolism in On-Stimulation compared with Off-Stimulation in the cingulate gyrus (Brodmann's area 24 and 32) and left frontal lobe (medial gyrus Brodmann's area 6) (p < .005). Transversal, sagittal, and coronal views projected onto brain slices of a standard magnetic resonance imaging (x,y,z Talairach coordinates).
Biological Psychiatry  , DOI: ( /j.biopsych )
Copyright © 2010 Society of Biological Psychiatry Terms and Conditions

5. Figure 4
Correlation between metabolic change induced by stimulation and concomitant clinical improvement. Whole-brain analysis shows a significant cluster of correlation in the ventromedial prefrontal cortex with the decrease in the Yale–Brown Obsessive Compulsive Scale score.
Biological Psychiatry  , DOI: ( /j.biopsych )
Copyright © 2010 Society of Biological Psychiatry Terms and Conditions