1. IMPLANT RESEARCH The University of São Paulo
Faculty of Dentistry of Ribeirão Preto
Department of Oral & Maxillofacial Surgery and Periodontics

3. IMPLANT RESEARCH Basic
BMP-2 as an adjuvant therapy for implant integration.
The fate of onlay iliac grafts.
Development of a resorbable device for sinus floor augmentation.
Clinical
Mono-cortical engaged and immediate loaded Astra™ implants.

4. BMP-2 as an adjuvant therapy for implant integration
Question:
Does BMP-2 improve osseointegration when implants are placed under challenging bony anchorage?

5. BMP as an adjuvant therapy for implant integration
Experimental Design:
Four defects (6.3 x 5.0mm) were trephined on each side of mandibular ridge crest in 12 dogs.
Fixtures (3.3 x 10.0mm) were inserted in the centre of each defect and the gap filled with either autogenous bone; BMP-2 plus carrier; carrier alone; or blood clot.
Animals sacrifice (6 and 12 weeks)
Evaluation:
Implant stability: RFA (Osstell™) at implant installation / sacrifice.
Histometry (BA and BIC).

7. RESULTS Machined implants Change of mplant stability (ISQ) Placement
-10 -5 5 10 15 20 25
Placement
4 weeks
12 weeks
Change of mplant stability (ISQ)
Control
Bone graft
BMP+carrier
Carrier

8. RESULTS Oxidized implants Change of mplant stability (ISQ) Placement
-10 -5 5 10 15 20 25
Placement
4 weeks
12 weeks
Change of mplant stability (ISQ)
Control
Bone graft
BMP+carrier
Carrier

9. The fate of onlay iliac grafts
Question:
What’s the implication of the timing of revascularization for onlay bone grafts volume and density?

10. The fate of onlay iliac grafts
Experimental Design:
Iliac crest grafts fixed bilaterally on the mandible (perforated and non-perforated beds) of 36 rabbits.
Animals sacrifice at 3, 5, 7, 10, 20 and 60 postoperative days.
Evaluation:
Tomography taken at both surgery and sacrifice times.
Immunohistochemistry (osteopontin, osteocalcin, type 1 collagen, PECAM and VEGF anti bodies).
Histology and histometry

12. RESULTS

13. Development of a resorbable device for sinus floor augmentation
Question:
Can we provide the implants the required primary stability without the use of autogenous bone graft and/or biomaterials for sinus floor augmentation?

14. Palma et al., Clin Implant Dent Relat Res. 2006; 8(1):11-24.

15. RESULTS
Palma et al., Clin Implant Dent Relat Res. 2006; 8(1):11-24.

17. Development of a resorbable device for sinus floor augmentation
Experimental Design:
8 monkeys (Cebus appela)
Baseline: dome-like device installed in both sinuses, one fixture in only one sinus.
6-month p.o.: 4 animals sacrificed. Remaining received second fixture in contra-lateral sinus.
9-month p.o.: 4 animals sacrificed.
Evaluation:
RFA (Osstell™) → 0, 6 and 9 months
Osseointegration (BA and BIC)
Histology

19. Curso de Implantodontia Avançada
CURSO DE APERFEIÇOAMENTO – UNIVERSIDADE DE SÃO PAULO
Local: Faculdade de Odontologia de Ribeirão Preto / USP
Início: 2a. Turma - Março 2007
Duração: 12 meses
Vagas: 10
Investimento: R$ 800,00 mensais
Informações: Depto. Cirurgia FORP-USP /
Tópicos:
Planejamento
Enxertos ósseos
Biomateriais
Levantamentos de
seio maxilar
Carga Imediata
Distração Osteogênica
Cirurgias Ambulatoriais
CirurgiasHospitalares
(observação)
Prof. Dr. Luiz A. Salata
FORP/USP
Prof. Dr. Samuel Xavier
FORP/USP
Prof. Dr. Lars Sennerby
Universidade de Gotemburgo
(Suécia)

20. CONEXÃO® Apoio: Sinus Lifting Enxertos Intra-orais
Distração Osteogênica
Apoio:
CONEXÃO®
Implantes Zigomáticos
Enxerto - Ilíaco
Enxerto – Calota Craniana
Carga Imediata

21. Monocortical engaged and immediate loaded Astra™ implants
Experimental Design:
10 mandible edentulous patients
4 fixtures installed at the anterior mandible
Same day loading (provisional fixed prosthesis)
Follow-up:
RFA (Osstell™) analysis → 0 and 6 months
Panoramic x-ray → 0 and 6 months

23. Monocortically engaged and immediate loaded Astra™ implants
Results: