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Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice  Sevtap Aydın, PhD, Mehmet Tokaç, MD, PhD, Gökçe Taner, MSc, Ata Türker Arıkök,

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Presentation on theme: "Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice  Sevtap Aydın, PhD, Mehmet Tokaç, MD, PhD, Gökçe Taner, MSc, Ata Türker Arıkök,"— Presentation transcript:

1 Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice 
Sevtap Aydın, PhD, Mehmet Tokaç, MD, PhD, Gökçe Taner, MSc, Ata Türker Arıkök, MD, PhD, Halit Ziya Dündar, MD, PhD, Alper Bilal Özkardeş, MD, PhD, Mine Yavuz Taşlıpınar, MD, PhD, Mehmet Kılıç, MD, PhD, Arif Ahmet Başaran, PhD, Nurşen Başaran, PhD  Journal of Surgical Research  Volume 182, Issue 2, Pages (June 2013) DOI: /j.jss Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Fig. 1 Hepatic TNF-α level in the experimental groups. Results were given as mean ± SD. a P < 0.05, group I compared with group II and group III. b P < 0.05, group II compared with group III. Journal of Surgical Research  , DOI: ( /j.jss ) Copyright © 2013 Elsevier Inc. Terms and Conditions

3 Fig. 2 DNA damages expressed as DNA tail length, DNA tail intensity, and DNA tail moment in the whole blood cells (A), lymphocytes (B), the liver (C), and renal (D) tissue cells of the experimental groups. aP < 0.05, group I compared with group II and group III. bP < 0.05, group II compared with group III. Journal of Surgical Research  , DOI: ( /j.jss ) Copyright © 2013 Elsevier Inc. Terms and Conditions

4 Fig. 3 Histopathology of hepatic tissue in group I (A), group II (B), and group III (C). Normal histological structure of liver was observed in group I (hematoxylin and eosin [H and E], ×20). There was portal inflammation, parenchymal necrosis, and ductal proliferation including bridging of the portal tracts in group II (H and E, ×20). Portal inflammation, parenchymal necrosis, and ductal proliferation attenuated markedly in group III compared with group II (H and E, ×10). (Color version of figure is available online.) Journal of Surgical Research  , DOI: ( /j.jss ) Copyright © 2013 Elsevier Inc. Terms and Conditions

5 Fig. 4 Histopathology of renal tissue in group I (A), group II (B), and group III (C). Normal histologic structure was observed in group I (H and E, ×20). There were glomerular and tubular damages in group II (H and E, ×20). The degenerations attenuated markedly in group III compared with group II (H and E, ×20). (Color version of figure is available online.) Journal of Surgical Research  , DOI: ( /j.jss ) Copyright © 2013 Elsevier Inc. Terms and Conditions


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