1. Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson#cod#x02019;s Disease
Natalya A. Smirnova 1, 2 ;Navneet Ammal Kaidery 3 ;Dmitry M. Hushpulian 2, 4 ;Ilay I. Rakhman 1 ;Andrey A. Poloznikov 2 ;Vladimir I. Tishkov 5 ;Saravanan S. Karuppagounder 1 ;Irina N. Gaisina 6 ;Anton Pekcec 7, # ;Klaus Van Leyen 7 ;Sergey V. Kazakov 8 ;Lichuan Yang 3, #cod#x00024; ;Bobby Thomas 3 ;Rajiv R. Ratan 1 ;Irina G. Gazaryan 1, 5, 8 ;
1 Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, NY 10605, USA ; 2 D. Rogachev Federal Scientific and Clinical Center for Pediatric Hematology, Oncology, and Immunology, Moscow , Russia ; 3 Departments of Pharmacology, Toxicology #cod#x00026; Neurology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA ; 4 ValentaPharm, Moscow , Russia ; 5 Department of Chemical Enzymology, Moscow State University, Moscow , Russia ; 6 Department of Medicinal Chemistry and Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA ; 7 Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA ; 8 Department of Chemistry and Physical Sciences, Dyson College, Pace University, Pleasantville, NY 10570, USA. ;
Figure Structural requirements for activating HIF1 ODD-luc reporter correspond to those for inhibiting HIF PHD2 . A 3,7-hydroxyflavone docking into PHD2 active site illustrating bi-ligand iron chelation via carbonyl oxygen and 3-hydroxygroup and interaction of 5-hydroxygrop with Met299; B docking of luteolin, active center view, and C overall view; D docking of 3#cod#x02019;-hydroxydaidzein, and E NDGA.
Aging and Disease,null,7(6), Doi: /AD