1. Dr. Hasan Hüseyin Gümüşcü1, Dr. Kevser Onbaşı1, Dr. Nilgün Kaşifoğlu2
Parvovirus B 19 infection may have a role have a role in the etiopathogenesis of type 1 DM
Dr. Hasan Hüseyin Gümüşcü1, Dr. Kevser Onbaşı1, Dr. Nilgün Kaşifoğlu2
Faculty of Medicine, Department of Internal Medicine and Endocrinology1 , Dumlupınar University, Kütahya, and Department of Microbiology 2, Eskişehir Osmanagzi University, Turkey.
INTRODUCTION
Parvovirus (Erythrovirus) B19 (EVB19) infection may trigger autoimmune diseases like SLE, RA, and vasculitis. Parvovirus B19 belongs to the parvoviridae family and to the erythrovirus genus (1,2). The etiopathogenesis of autoimmune diabetes mellitus could not been explained yet. The aim of our study was to investigate whether EVB19 may have a role in the etiopathogenesis of type 1 DM. Therefore have we examined whether EVB19 is more frequent among type 1 diabetics.
Methods:
32 patients with type 1 diabetes and 30 control patients were included in the study. 25 of the 32 type 1 diabetic patients had parvovirus B19 IgG positive sera. The seroprevalence of IgG parvovirus B19 among controls were in 16 of 30 persons. This was statistically significant (p level was 0,039). 25-OH vitamin D levels were lower among Parvovirus B19 IgG seropositive patients than seronegative patients. This may be related to the fact that the immune status is impaired in vitamin D insufficiency.
None of our patients had IgM positive sera for parvovirus B 19. This suggests that there was no acute infection.
There was no significant change of HbA1c levels between the negative and positive patients.
Table 1: Mean Vit D levels for seropositive and negative patients
Table 2: Mean vit D levels for patients and control group
Erythrovirus B19 (EVB19) has been incriminated, over recent years, in the onset and/or pathogenesis of many autoimmune diseases (3).
CONCLUSION
In conclusion, parvovirus B19 infection may play a role in triggering type 1 diabetes and low vitamin D levels may increase susceptibility to parvovirus B 19 infection.
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