1. Perelman School of Medicine University of Pennsylvania
Comments on the Milano-PILOT Trial AHA Scientific Sessions Late Breaking Clinical Trials November 15, 2016
Daniel J. Rader, MD
Perelman School of Medicine
University of Pennsylvania

2. ApoA-I Milano

3. Nissen SE et al. JAMA 2003;290:2292–2300.

4. Nissen SE et al. JAMA 2003;290:2292–2300.

5. MILANO-PILOT Well-executed IVUS trial by world class investigators
Three times the size of the original apoA-I Milano IVUS trial
Convincing negative results

7. Reconstituted HDL products with wild-type apoA-I in clinical development
CSL112
CER001

8. Reverse Cholesterol Transport
Bile
A-I
A-I
ABCG1 FC CE FC
LCAT FC FC CE
SR-BI
ABCA1
Liver
Macrophage

9. ApoA-I Milano differs from wild-type apoA-I with regard to several functions
Structure

10. ApoA-I Milano differs from wild-type apoA-I with regard to several functions
Structure
Generation of pre-beta HDL

11. ApoA-I Milano differs from wild-type apoA-I with regard to several functions
Structure
Generation of pre-beta HDL
Promotion of cholesterol efflux

12. ApoA-I Milano differs from wild-type apoA-I with regard to several functions
Structure
Generation of pre-beta HDL
Promotion of cholesterol efflux
Activation of LCAT