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Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower.

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Presentation on theme: "Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower."— Presentation transcript:

1 Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: Dose-response effect of basic fibroblast growth factor  Richard Baffour, PhD, Joel Berman, MD, Jane L. Garb, MS, Sang Won Rhee, MD, Jeffrey Kaufman, MD, Paul Friedmann, MD  Journal of Vascular Surgery  Volume 16, Issue 2, Pages (August 1992) DOI: / (92)90106-I Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Surgical procedure is shown; second stage is performed 1 week later. Journal of Vascular Surgery  , DOI: ( / (92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Experimental protocol.
Journal of Vascular Surgery  , DOI: ( / (92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Representative angiograms; Angiographic evidence of revascularization by exogenous bFGF are compared. A, saline control; B, 1 μg bFGF; C, 3 μg bFGF animals. Journal of Vascular Surgery  , DOI: ( / (92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Comparison of treatment groups on TcPo2 measurements on days 1, 7, and 14. Journal of Vascular Surgery  , DOI: ( / (92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 Representative histologic sections; Left thigh; vastus medialis muscle sections histochemically stained for alkaline phosphatase activity. Dark spots represent capillaries. (A) saline control (× 250); (B) 1 μg bFGF (× 250); (C) 3 μg bFGF (× 250). Journal of Vascular Surgery  , DOI: ( / (92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7 Fig. 6 Comparison of treatment groups on muscle TTC reduction.
Journal of Vascular Surgery  , DOI: ( / (92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


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