1. Mouse Double Minute 2 (MDM2)
Kirubel Asfaw

2. MDM2 Discovery
Momand et al

3. MDM2 inhibits p53
p53.free.fr

4. p53 Cellular Functions Master control of cell cycle
It is a transcription factor.
Responds to cellular stresses by activating growth arrest or apoptosis

5. Mechanisms of Inhibition
p53.free.fr

6. Phosphorylation activates p53
p53.free.fr

7. MDM2 cellular functions in normal cells
Cell survival
Cell cycle progression

8. MDM2’s ability to control p53 is essential during development
p53.free.fr
Jones et al

9. MDM2 is an oncogene
MDM2 overexpression blocks p53-mediated cell-cycle arrest and apoptosis.

10. MDM2 protein overexpression due to SNPs

11. Analysis of 3000 tumor samples shows that MDM2 is amplified in 7% of these tissues.
Momand et al

12. MDM2 protein overexpression due to gene amplification
Wikepedia.org

13. SNP309 polymorphism was detected in 232 (68%) of 343 familial breast cancer cases
Wasielewski et all

14. No MDM2 gene amplification was observed in the presence of mutated p53 gene
Pollock et al

15. The p53-MDM2 interface is a target for cancer therapy