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In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin  Kristiina M. Huttunen, Jukka Leppänen, Jouko Vepsäläinen, Jouni Sirviö, Krista.

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Presentation on theme: "In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin  Kristiina M. Huttunen, Jukka Leppänen, Jouko Vepsäläinen, Jouni Sirviö, Krista."— Presentation transcript:

1 In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin 
Kristiina M. Huttunen, Jukka Leppänen, Jouko Vepsäläinen, Jouni Sirviö, Krista Laine, Jarkko Rautio  Journal of Pharmaceutical Sciences  Volume 101, Issue 8, Pages (August 2012) DOI: /jps.23221 Copyright © 2012 Wiley Periodicals, Inc. Terms and Conditions

2 Figure 1 Proposed bioactivation of cyclohexyl sulfenamide prodrug of metformin (1) by glutathione. Journal of Pharmaceutical Sciences  , DOI: ( /jps.23221) Copyright © 2012 Wiley Periodicals, Inc. Terms and Conditions

3 Figure 2 Octanol–water distribution coefficient (log D) of metformin and prodrug 1 at pH values of 4.0 and 7.4 at room temperature (n = 3). Journal of Pharmaceutical Sciences  , DOI: ( /jps.23221) Copyright © 2012 Wiley Periodicals, Inc. Terms and Conditions

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