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Post-operative antiplatelet therapy following coronary artery bypass graft surgery
Rory Kelleher, Josephine Mak, David J McCormack, Adam El Gamel Waikato Cardiothoracic Unit
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BACKGROUND saphenous vein most common in CABG
early graft failure - thrombosis DAPT improves prognosis Benefits: prevents graft closure Risks: bleeding
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AIM… to prevent…! Acute thrombosis of SVG
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CURRENT recommendations
2016 ACC/AHA GUIDLINE - aspirin and clopidogrel should be continued in ACS & SIHD patients for one year postoperatively
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AIM to evaluate the received postoperative antiplatelet therapy of CABG patients at discharge
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METHODS 3 months of post-cabg patients (Jan-March 2016) 69 patients
patients on anticoagulant therapy excluded discharge summaries analysed antiplatelet medications prescribed duration of proposed antiplatelet therapy
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RESULTS DAPT on discharge summaries was markedly varied
17 different regimens were found Varying length of therapy and agents most common regimen: 3 months aspirin & 3 months clopidogrel (27 patients) No pattern in prescribing when patients separated according to preoperative status (ACS, SIDH or PCI)
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DISCUSSION cardiology 6 weeks post-op, meds changed?
Max length prescription 3 months duration should be in discharge plan Should be clearly documented by the cardiothoracic team GPs and cardiologists Rely too heavily on cardiologists? Need for a protocol?
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conclusion DAPT not being documented appropriately at discharge
Requirement for an intervention Applying best practice may help future research to compare the efficacy of percutaneous stents with CABG.
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HOW CAN WE IMPROVE?
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Solution? postoperative antiplatelet card
issued to patients listing the current guidelines, antiplatelet prescribed and the rationale for choosing this regimen. Promotes patient empowerment
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Future research Closed loop audit – repeat 3 months following intervention Are cardiologists changing antiplatelets at 6 weeks? Contact gp’s – are patients still on antiplatelets at 12 months?
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Cardiologists AND CT surgeons – team. not one or the other.
Update guidelines Implement change Educate staff Improve care
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REFERENCES Harskamp RE, Lopes RD, Baisden CE, de Winter RJ, Alexander JH. Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions. Ann Surg. 2013; 257(5): Bong Gun Song, Hyun Suk Yang, Joon Hyung Doh, Hong Jang, Gu Hyun Kang, Yong Hwan Park, Woo Jung Chun, Ju Hyeon Oh, Sung Min Ko and Hweung Kon Hwang (2011). Assessment of Coronary Artery Bypass Graft (CABG) Patency and Graft Disease Using Multidetector Computed Tomography (MDCT), Coronary Angiography - Advances in Noninvasive Imaging Approach for Evaluation of Coronary Artery Disease, Prof. Baskot Branislav (Ed.), InTech, DOI: / Available from: coronary-artery-bypass-graft-cabg-patency-and-graft-disease-using-multidetector-comput Fox KA, Mehta SR, Peters R, et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial. Circulation 2004; 110:1202. Glenn N. Levine, Eric R. Bates, John A. Bittl, Ralph G. Brindis, Stephan D. Fihn, Lee A. Fleisher, Christopher B. Granger, Richard A. Lange, Michael J. Mack, Laura Mauri, Roxana Mehran, Debabrata Mukherjee, L. Kristin Newby, Patrick T. O’Gara, Marc S. Sabatine, Peter K. Smith and Sidney C. Smith ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2016; 136: 2. Deo, S. V., Dunlay, S. M., Shah, I. K., Altarabsheh, S. E., Erwin, P. J., Boilson, B. A., Park, S. J. and Joyce, L. D. Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting: Is There Any Benefit? A Systematic Review and Meta-Analysis. J Card Surg. 2013; 28: 109 Kulik A, Ruel M, Jneid H, Ferguson TB, Hiratzka LF, Ikonomidis JS, Lopez-Jimenez F, McNallan SM, Patel M, Roger VL, Sellke FW, Sica DA, Zimmerman L. Secondary prevention after coronary artery bypass graft surgery: a scientific statement from the American Heart Association. Circulation. 2015; 131: Farooq V, Serruys PW, Bourantas C, Vranckx P, Diletti R, Garcia Garcia HM, Holmes DR, Kappetein AP, Mack M, Feldman T, Morice MC, Colombo A, Morel MA, de Vries T, van Es GA, Steyerberg EW, Dawkins KD, Mohr FW, James S, Ståhle E. Incidence and multivariable correlates of long-term mortality in patients treated with surgical or percutaneous revascularization in the Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) trial. Eur Heart J. 2012;33:3105– 3113.
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