1. Immunization Update 2007 Rotavirus Vaccine Segment
Satellite Broadcast/Webcast
August 9, 2007
Rotavirus Vaccine Segment
Graphics subject to change.
This material in the public domain.

2. Burden of Rotavirus Disease in the United States
3 million infections every year
More than 400,000 physician visits
200,000 emergency dept visits
55,000-70,000 hospitalizations
deaths
Source: MMWR 2006;55 (RR-12)

3. Rotavirus Vaccines Created by genetic reassortment
causes nonhuman rotavirus strains to express human rotavirus antigens on their surface
nonhuman rotaviruses have low pathogenicity for humans
replicate but do not cause disease

4. Rotashield and Intussusception
Significantly increased risk of intussusception among infants who received Rotashield
Highest risk was observed 3-7 days after the first dose
Resulted in the vaccine being taken off the market in late 1999

5. Rotavirus Vaccine and Intussusception
Recipients
6 cases
13 cases
Placebo
Recipients
5 cases
15 cases
Within 42 days
of vaccination
Within 1 year
Source: New Eng J Med 2006;354:23-33

6. RotaTeq Intussusception Reports Received by VAERS*
117 confirmed reports
38 cases 1-21 days after vaccination
23 cases 1-7 days after vaccination
about one third of 38 cases occurred following the first dose
6 million vaccine doses distributed
*March 2006 through mid-June 2007

7. Expected and Reported Cases of Intussusception After RotaTeq
Age Group
Number Expected*
Number Reported
6-14 30 14
15-23 36
24-35 33 10
Total 99 38
*Among children 6-35 weeks of age, within 21 days
of a dose based on VSD data

8. Rotavirus Vaccine Recommendations
3 oral doses at 2, 4, and 6 months of age
Series may be started as early as 6 weeks of age
First dose should be administered between 6 and 12 weeks of age
Vaccination should NOT be initiated for infants older than 12 weeks of age
Minimum interval between subsequent doses is 4 weeks
Source: MMWR 2006;55 (RR-12)

9. Rotavirus Vaccine Recommendations
All 3 doses of vaccine should be administered by 32 weeks of age
Vaccine should NOT be administered after 32 weeks of age
Source: MMWR 2006;55 (RR-12)

10. Website www.cdc.gov/nip
CDC Vaccines and Immunization Contact Information
Hotline (800) CDC-INFO
Website
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