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Rotavirus vaccines: Successes and challenges

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1 Rotavirus vaccines: Successes and challenges
Roger I. Glass, Umesh Parashar, Manish Patel, Jon Gentsch, Baoming Jiang  Journal of Infection  Volume 68, Pages S9-S18 (January 2014) DOI: /j.jinf Copyright © Terms and Conditions

2 Figure 1 Electron micrograph of rotavirus particles in stool of a child with rotavirus diarrhea (Marker represents 100 microns). Journal of Infection  , S9-S18DOI: ( /j.jinf ) Copyright © Terms and Conditions

3 Figure 2 National rotavirus vaccine introductions by geographic region: 47 countries shown. ∗Courtesy of PATH at: Journal of Infection  , S9-S18DOI: ( /j.jinf ) Copyright © Terms and Conditions

4 Figure 3 Distribution of global rotavirus mortality, *From Ref. 36 [author's (UDP) own data]. Journal of Infection  , S9-S18DOI: ( /j.jinf ) Copyright © Terms and Conditions

5 Figure 4 Direct and indirect benefits of vaccine as evidenced by reduction in severe rotavirus diarrhea among vaccinated and unvaccinated children after the introduction of a rotavirus vaccine in various countries. *Adapted from Table 4, Ref. 5. Journal of Infection  , S9-S18DOI: ( /j.jinf ) Copyright © Terms and Conditions

6 Figure 5 Decline in diarrhea deaths among children under 5 after the introduction of rotavirus vaccine in Mexico in *From Ref. 53 [authors' own (MMP, UDP) data]. Journal of Infection  , S9-S18DOI: ( /j.jinf ) Copyright © Terms and Conditions

7 Figure 6 Factors suspected to interfere with “take” of oral rotavirus vaccine in low-income settings. *Adapted from Ref. 47. Journal of Infection  , S9-S18DOI: ( /j.jinf ) Copyright © Terms and Conditions


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