1. Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer
Digestion 2011;83:241– DOI: /
Fig. 1.a DNA methyltransferases (DNMTs) catalyze the methylation of cytosine using S-adenosylmethionine (SAM) as the methyl donor. b DNA methylation is maintained after DNA replication by a maintenance DNA methyltransferase, DNMT1.
© 2011 S. Karger AG, Basel

2. Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer
Digestion 2011;83:241– DOI: /
Fig. 2. Methylation of a CpG island within a gene promoter and transcriptional silencing. a In normal cells, most CpG islands are unmethylated, and gene transcription is active. b In cancer cells, the CpG islands of a number of genes are hypermethylated, which results in transcriptional silencing of the genes.
© 2011 S. Karger AG, Basel

3. Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer
Digestion 2011;83:241– DOI: /
Fig. 3. Association between fold width, histological type and location of gastric cancers. The results are derived from Nishibayashi et al. [5].
© 2011 S. Karger AG, Basel

4. Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer
Digestion 2011;83:241– DOI: /
Fig. 4. Hypothesis for the progression of gastric cancer in H. pylori-induced enlarged-fold gastritis.
© 2011 S. Karger AG, Basel