1. Heidi Kaspersen and Martine Sakariassen
Migraine
Heidi Kaspersen and Martine Sakariassen

2. What is migraine? Chronic disorder Recurrent attacks of headache
Complex neurobiological disorder
Core features: Headache, nausea, light and sound sensitivity etc.
Migraine predisposition varies individually

3. Phases of migraine

4. Pathophysiology of migraine
Several theories trying to explain the etiology of migraine
The most accepted ones are the vascular and neurovascular theories

5. Neurovascular theory Cortical depression spreding (CDS)
- Reduction in brain electrical activity and decrease blood flow
- Release of K+ and H+ activates sensory fibers
- Activation of trigeminal & brain stem neurons
- Precipitation of vasodilation

6. Genetic component Strong familial influence proved in twinstudies
Mutations in voltage gated calcium channels seen in many families, predisposing to migraine
Related to serotonin release in midbrain

7. Migraine and neuropsychiatric disorders
Comorbid disorders, such as depression, anxiety, panic disorder and bipolar disorder.
There are several researches and theories explaining the associations.

8. Migraineurs VS non-migraineurs

9. Treatment Pharmacological and non-pharmacological approaches
Pharmalogical: NSAIDs (Aspirin, Ketoprofen), Erogot alkaloids, Triptans
Non-pharmacological: Cold packs to the head, Riboflavin and Magnesium
Medication of prevention:
- 1st line: Propanolol, Amitriptylin
- 2nd line: Valproat, Pisotifen

10. Sources