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Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in.

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Presentation on theme: "Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in."— Presentation transcript:

1 Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?  Leos Kren, Katarina Muckova, Eva Lzicarova, Marek Sova, Vaclav Vybihal, Tomas Svoboda, Pavel Fadrus, Martin Smrcka, Ondrej Slaby, Radek Lakomy, Petr Vanhara, Zdenka Krenova, Jaroslav Michalek  Journal of Neuroimmunology  Volume 220, Issue 1, Pages (March 2010) DOI: /j.jneuroim Copyright © 2010 Elsevier B.V. Terms and Conditions

2 Fig. 1 Positivity of extravillous trophoblast for the HLA-G clone MEM-G/1 (a), clone MEM-G/2 (b) and HLA-E (c). Villous trophoblast shows no reactivity, 200×. Journal of Neuroimmunology  , DOI: ( /j.jneuroim ) Copyright © 2010 Elsevier B.V. Terms and Conditions

3 Fig. 2 Positivity of activated microglia/macrophages for CD 68. Background glioblastoma cells show no reaction, 400×. Journal of Neuroimmunology  , DOI: ( /j.jneuroim ) Copyright © 2010 Elsevier B.V. Terms and Conditions

4 Fig. 3 Positivity of activated microglia/macrophages for the HLA-G clone MEM-G/1 (a), clone MEM-G/2 (b) and HLA-E (c), 400×. Journal of Neuroimmunology  , DOI: ( /j.jneuroim ) Copyright © 2010 Elsevier B.V. Terms and Conditions

5 Fig. 4 Co-localisation double immunohistochemistry for CD 68 (light granular red, insets) and HLA-G clone MEM-G/1 (a), clone MEM-G/2 (b) and HLA-E (c), immersion 1000×. Journal of Neuroimmunology  , DOI: ( /j.jneuroim ) Copyright © 2010 Elsevier B.V. Terms and Conditions

6 Fig. 5 Positivity of endothelial cells in normal brain tissue for HLA-E, 400×. Journal of Neuroimmunology  , DOI: ( /j.jneuroim ) Copyright © 2010 Elsevier B.V. Terms and Conditions

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