1. Chapter 5: Treatment of hypertension in patients receiving cancer therapy
Aaron P Kithcart
Giuseppe Curigliano
Joshua A. Beckman
Cardio-Oncology
Eds: Kimmick, Lenihan, Sawyer, Mayer, Hershman

2. Vandetanib reduced plasma nitrite levels (adapted from Mayer et al 2011)

3. Classification of Normal Blood Pressure and Hypertension
Systolic BP (mm Hg)
Diastolic BP (mm Hg)
Normal
< 120
< 80
Prehypertension
80-89
Stage 1
90-99
Stage 2
> 160
> 100

4. Common Terminology Criteria for Adverse Events for Hypertension
GRADE 1 2 3 4 5
Prehypertension (systolic BP mm Hg or diastolic BP mm Hg)
Stage 1 hypertension (systolic BP mm Hg or diastolic BP mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated
Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated
Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated
Death