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Biocompatible Microemulsion Modifies the Pharmacokinetic Profile and Cardiotoxicity of Doxorubicin  Juliana Uruguay Correa Vidigal AssumpçãO, Michel Leandro.

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Presentation on theme: "Biocompatible Microemulsion Modifies the Pharmacokinetic Profile and Cardiotoxicity of Doxorubicin  Juliana Uruguay Correa Vidigal AssumpçãO, Michel Leandro."— Presentation transcript:

1 Biocompatible Microemulsion Modifies the Pharmacokinetic Profile and Cardiotoxicity of Doxorubicin 
Juliana Uruguay Correa Vidigal AssumpçãO, Michel Leandro Campos, Marco Antonio Ferraz Nogueira Filho, Kelly Chrystina Pestana, Helen Mariana Baldan, Thalita Pedroni Formariz Pilon, Anselmoc Gomes de Oliveira, Rosângela Gonçalves Peccinini  Journal of Pharmaceutical Sciences  Volume 102, Issue 1, Pages (January 2013) DOI: /jps.23368 Copyright © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association Terms and Conditions

2 Figure 1 Chromatograms (a) plasma zero, (b) DOX 5 μg/mL in plasma spiked with IS (DAU). Journal of Pharmaceutical Sciences  , DOI: ( /jps.23368) Copyright © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association Terms and Conditions

3 Figure 2 Mobile phase DOX calibration curve.
Journal of Pharmaceutical Sciences  , DOI: ( /jps.23368) Copyright © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association Terms and Conditions

4 Figure 3 Plasma DOX calibration curve.
Journal of Pharmaceutical Sciences  , DOI: ( /jps.23368) Copyright © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association Terms and Conditions

5 Figure 4 Serum CKMB activity in two groups of male Wistar rats: treated with commercial DOX and DOX‐ME. *p < 0.05 (ANOVA followed by tukey test). Journal of Pharmaceutical Sciences  , DOI: ( /jps.23368) Copyright © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association Terms and Conditions

6 Figure 5 DOX kinetic disposition. Single i.v. dose (6 mg/kg): DOX commercial and DOX‐ME administered in two male Wistar rat groups (n = 12). Journal of Pharmaceutical Sciences  , DOI: ( /jps.23368) Copyright © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association Terms and Conditions

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