1. Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation 
Bridget D Stuart, MD, Joyce S Lee, MD, Julia Kozlitina, PhD, Prof Imre Noth, MD, Megan S Devine, MD, Craig S Glazer, MD, Fernando Torres, MD, Vaidehi Kaza, MD, Prof Carlos E Girod, MD, Prof Kirk D Jones, MD, Brett M Elicker, MD, Shwu-Fan Ma, PhD, Rekha Vij, MD, Harold R Collard, MD, Paul J Wolters, MD, Dr Christine Kim Garcia, MD 
The Lancet Respiratory Medicine 
Volume 2, Issue 7, Pages (July 2014)
DOI: /S (14)
Copyright © 2014 Elsevier Ltd Terms and Conditions

2. Figure 1
Age-adjusted telomere lengths in patients with interstitial lung disease in the Dallas cohort and controls
Mean observed minus expected (O–E; age-adjusted) telomere length for controls (n=195), patients' spouses (n=46), and individuals from familial pulmonary fibrosis kindreds who carry an inherited telomerase (TERT or TERC) mutation (n=106). The patients with interstitial lung disease were subdivided by cause: idiopathic pulmonary fibrosis (IPF, n=149) and non-IPF, which includes connective-tissue disease-associated interstitial lung disease (CTD-ILD, n=126), idiopathic interstitial pneumonias other than usual interstitial pneumonia (other IIPs, n=17), hypersensitivity pneumonitis (n=30), drug-related or radiation-associated interstitial lung disease (exposures, n=10), sarcoidosis (n=22), and interstitial lung disease from other causes (other, n=16). The mean telomere lengths (relative T/S) of the main control cohort and the spouse control group are 1·55 (SD 0·21) and 1·51 (0·22), which correspond to mean age-adjusted telomere lengths (O–E) of 0·00 (0·18) and 0·01 (0·20), respectively. The mean telomere lengths (relative T/S) of the Dallas IPF and the combined non-IPF cohort are 1·33 (SD 0·25) and 1·46 (0·24), which correspond to mean age-adjusted telomere lengths (O–E) of −0·16 (0·23) and −0·09 (0·22), respectively. Thick short purple lines show the median for each subgroup. The black dotted line shows the median telomere length of the main control group; approximate age-adjusted prediction bands (percentiles; blue dotted lines) were calculated from the linear regression model for the main control group. *p<0·05. ***p<0·0005. NS=not significant (p≥0·05).
The Lancet Respiratory Medicine 2014 2, DOI: ( /S (14) )
Copyright © 2014 Elsevier Ltd Terms and Conditions

3. Figure 2
Transplant-free survival according to telomere length in patients with idiopathic pulmonary fibrosis in each cohort
Transplant-free survival was estimated for patients with idiopathic pulmonary fibrosis from the Dallas cohort (A), Chicago cohort (B), and San Francisco cohort (C), stratified by telomere length quartiles. IPF=idiopathic pulmonary fibrosis.
The Lancet Respiratory Medicine 2014 2, DOI: ( /S (14) )
Copyright © 2014 Elsevier Ltd Terms and Conditions