1. Chapter 23
Fatty Acid Catabolism

2. (Oxidation of Fatty Acids):
Page 697
Fatty Acid Catabolism
(Oxidation of Fatty Acids):
1.Saturated fatty acids
2.Unsaturated fatty acids
3.Ketogenesis 酮體生成

3. Overview of Fatty Acid Metabolism

4. Triacylglycerols Are a Major Form of Stored Energy in Animals Page 698
*triacylglycerol lipase
(also called hormone-sensitive lipase)

5. Degradation of Dietary Fatty Acids Occurs Primarily In the Duodenum
Page 699

6. Small Intestine
Page 700
十二指腸 空腸 迴腸

7. Page 700

8. Fatty Acids Are Activated before They Are Degraded
Page 702
*synthase

9. CoA Activates FAs for Oxidation and Carnitine
as a Carries for Long-Chain FAs
Page 703
(carnitine
acyltransferase II)

10. Page 703
acylcarnitine

11. b oxidation
Page 701

12. (Oxidation of Fatty Acids):
Page 704
Fatty Acid Catabolism
(Oxidation of Fatty Acids):
1.Saturated fatty acids
2.Unsaturated fatty acids
3.Ketogenesis

13. Saturated Fatty Acids
Page 704
*Even-Carbon
(thiolase I)

14. Acyl-CoA Dehydrogenase
Page 705
VLCAD: very long acyl-CoA dehydrogenase

15. Page 704

16. Page 704

17. Fatty Acid Oxidation Is an Important Source of
Metabolic Water for Some Animals
Page 709
1 acetyl -CoA: 1FADH2+3NADH+1ATP=1x1.5+3x2.5+1=10

18. Page 565

19. Odd-Carbon Fatty Acids
Page 711

20. Page 713
Succinyl-CoA
malic enzyme

21. (Oxidation of Fatty Acids):
Fatty Acid Catabolism
(Oxidation of Fatty Acids):
1.Saturated fatty acids
2.Unsaturated fatty acids
3.Ketogenesis

22. Monounsaturated Fatty Acids
Page 714

23. Polyunsaturated Fatty Acids
Page 715

24. Other Ways to Oxidize Fatty Acids
Page 714 & 716
Other Ways to Oxidize Fatty Acids
Peroxisomal -oxidation
Branched-chain -oxidation
-oxidation

25. Page 714
Peroxisomal b-Oxidation
‧Peroxisomes that carry out flavin-dependent oxidations, regenerating oxidized flavins by reaction with O2 to produce H2O2
Similar to mitochondrial -oxidation, but initial double bond formation is by acyl-CoA oxidase
Electrons go to O2 rather than e- transport
Fewer ATPs result

26. Page 714

27. Page 714
Branched-chain -oxidation
Branched chain FAs with branches at odd-number carbons are not good substrates for -oxidation
-oxidation is an alternative
Phytanic acid -oxidase decarboxylates with oxidation at the alpha position
-oxidation occurs past the branch

28. Page 716

29. Page 717
-oxidation

30. (Oxidation of Fatty Acids):
Fatty Acid Catabolism
(Oxidation of Fatty Acids):
1.Saturated fatty acids
2.Unsaturated fatty acids
3.Ketogenesis

31. Overview of Fatty Acid Metabolism

32. Ketone Bodies
Page 718
(thiolase II)

33. Page 717
Ketonemia

34. Ketone Bodies & Diabetes
Page 664

35. Page 565
Ketone Bodies & Diabetes

36. Large Amounts of Ketone Bodies Are Produced in Diabetes Mellitus
Page 717
Type I diabetes(IDDM; insulin-dependent diabetes mellitus)
Type II diabetes(NIDDM; non-insulin-dependent diabetes mellitus)
*glucose transporter
*insulin resistance

37. Exercise Can Reverse the Consequences of Metabolic Syndrome
Page 708

38. Can Natural Antioxidants in Certain Foods Improve Fat Metabolism?
Page 713
Tea Plants

39. Can Natural Antioxidants in Certain Foods Improve Fat Metabolism?
Page 713

40. Can Natural Antioxidants in Certain Foods Improve Fat Metabolism?
Page 713