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Volume 104, Issue 11, Pages (November 2010)

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Presentation on theme: "Volume 104, Issue 11, Pages (November 2010)"— Presentation transcript:

1 Volume 104, Issue 11, Pages 1608-1617 (November 2010)
Omalizumab-induced decrease of FcɛRI expression in patients with severe allergic asthma  Pascal Chanez, Cécile Contin-Bordes, Gilles Garcia, Christophe Verkindre, Alain Didier, Frédéric De Blay, Manuel Tunon de Lara, Patrick Blanco, Jean-François Moreau, Philip Robinson, Isabelle Bourdeix, Patrick Trunet, Vincent Le Gros, Marc Humbert, Mathieu Molimard  Respiratory Medicine  Volume 104, Issue 11, Pages (November 2010) DOI: /j.rmed Copyright © Terms and Conditions

2 Figure 1 Patient flow. All patients receiving one dose of study medication with at least one post-dose efficacy assessment were included in the Intent-To-Treat (ITT) population. The patients with missing pre- and/or post-treatment assessment(s) of FcɛRI expression were excluded from the ITT FcɛRI analyzable population for the primary endpoint. Abnormal laboratory result refers to serum IgE outside dosing table for omalizumab and abnormal test procedure refers to a technical issue with serum IgE determination. Respiratory Medicine  , DOI: ( /j.rmed ) Copyright © Terms and Conditions

3 Figure 2 Change in FcɛRI expression on basophils and plasmacytoid dendritic cells (pDC2) at the end of study relative to baseline. The change in FcɛRI expression (mean fluorescence intensity, MFI) on (a) basophils and (b) pDC2 for individual patients in the omalizumab and placebo groups are shown. Median values are indicated by a solid bar to the right of each plot. Difference between median change found in omalizumab and placebo groups was statistically significant for (a) basophils p < 0.01 and (b) pDC2 p = 0.029. Respiratory Medicine  , DOI: ( /j.rmed ) Copyright © Terms and Conditions

4 Figure 3 FcɛRI expression (MFI) on basophils in response to treatment in physician evaluated responders and non-responders (ITT FcɛRI analyzable population). Filled squares: omalizumab responders (n = 6), empty squares: omalizumab non-responders (n = 9), filled circles: placebo responders (n = 3), empty circles: non-responders (n = 6). Respiratory Medicine  , DOI: ( /j.rmed ) Copyright © Terms and Conditions

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