1. Meredith Tilley, PharmD Candidate Cone Health Family Medicine
News You Can Use…
Meredith Tilley, PharmD Candidate
Pete Koval, PharmD
Cone Health Family Medicine
December, 2016

2. Brand-to-Generic Switch
Benicar® is now available generically as olmesartan
Now, 6 of 8 ARBs in the U.S. are generically available
Other generic ARBs
Atacand® (candesartan)
Avapro® (irbesartan)
Cozaar® (losartan)
Diovan® (valsartan)
Micardis® (telmisartan)

3. FDA Approval Vemlidy® (tenofovir alafenamide, TAF)
For the treatment of chronic Hepatitis B Virus Infection
Similar efficacy to tenofovir fumarate, TDF, but at one tenth of the dose
Dose: 25 mg Daily
Improved renal and bone safety

4. FDA Approval
Bonjesta® (doxylamine succinate and pyridoxine HCL) extended release
For the treatment of nausea and vomiting in pregnancy for women who do not respond to conservative management
Dose: 20 mg QHS
Max dose: 20 mg BID
ADEs: somnolence
Bonjesta® [Package Insert] Bryn Mawr, PA: Duchesnay Inc; 2016

5. FDA Approval Insulin + GLP1 Fixed Combos
Xultophy 100/3.6
Soliqua 100/33
Insulin degludec
100 units/ml +
Liraglutide mg/ml
Max dose: 50 Units insulin degludec
Insulin glargine
100 units/ml +
Lixisenatide 33 mcg/ml
Max dose: 60 Units insulin glargine

6. Pipeline Medication Erenumab Phase III trial expected launch 2018
Found to reduce migraine days by 40%
MOA: blocks CGRP receptor
Once monthly injection

7. Tobacco update
New CDC study found that 40% of all cancers are linked to tobacco use
Events related to US tobacco use yearly
660,000 diagnoses
343,000 deaths

8. USPSTF update
New updates on recommendation on treating lipid disorders in adults
Initiate low- to moderate- intensity statins in
Adults w/out Hx of CVD and
>1 CVD risk factor & 10-year risk >10% (B) Or
>1 CVD risk factor & 10-year risk % (C)
Age >75 – Primary Prevention (Insuff. Evid.)

9. CDC Vaccine Update Changes to HPV Vaccine Doses
Ages 9-14 – only need 2 doses
Administer doses at least 6 months apart
Ages – continue 3 dose schedule