1. Sachin S Kale;Sachin Yende;
Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness
Sachin S Kale;Sachin Yende;
The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA ;
Figure 2 Conceptual model showing the relationship between inflammationhemostasis abnormalities throughout the continuum of critical illness and aging Aging is associated with a baseline increase in inflammation and hemostasis abnormalities dark black line. Three potential outcomes are shown following sepsis. Younger adults have a lower incidence and mortality with and are expected to return to baseline inflammatory and hemostasis levels after infection A. In older adults, a higher baseline inflammationhemostasis burden increases the risk of sepsis and higher mortality B. Even among older survivors of sepsis, processes that down-regulate inflammation after infection may be dysregulated, leading to a higher inflammationhemostasis burden post-infection and worse long-term outcomes, including repeat infection and exacerbation of chronic conditions C.
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