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Survival analysis for valproic acid use in adult glioblastoma multiforme: A meta-analysis of individual patient data and a systematic review  Yang Yuan,

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Presentation on theme: "Survival analysis for valproic acid use in adult glioblastoma multiforme: A meta-analysis of individual patient data and a systematic review  Yang Yuan,"— Presentation transcript:

1 Survival analysis for valproic acid use in adult glioblastoma multiforme: A meta-analysis of individual patient data and a systematic review  Yang Yuan, Wang Xiang, Mao Qing, Liu Yanhui, Luo Jiewen, Mao Yunhe  Seizure - European Journal of Epilepsy  Volume 23, Issue 10, Pages (November 2014) DOI: /j.seizure Copyright © 2014 British Epilepsy Association Terms and Conditions

2 Fig. 1 Pooled number of patients and percentage of included studies.
Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2014 British Epilepsy Association Terms and Conditions

3 Fig. 2 Forrest plot of the studies reporting a primary outcome.
Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2014 British Epilepsy Association Terms and Conditions

4 Fig. 3 Sub-group analysis.
Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2014 British Epilepsy Association Terms and Conditions

5 Fig. 4 Schematic illustration of VPA and HDAC's influence on cell cycle regulation. ERK: extracellular signal-regulated kinase; HDAC: histone deacetylases. 5-LOX, 5-lipoxygenase; eNOS, endothelial nitric-oxide synthase; JNK, c-jun N-terminal kinase; VPA: valproic acid. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2014 British Epilepsy Association Terms and Conditions


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