1. Volume 59, Issue 3, Pages 1094-1102 (March 2001)
Tubular stress test detects subclinical reduction in renal functioning mass 
Bernardo Rodríguez-Iturbe, José Herrera, Crispín Marín, Reinaldo Mañalich 
Kidney International 
Volume 59, Issue 3, Pages (March 2001)
DOI: /j x
Copyright © 2001 International Society of Nephrology Terms and Conditions

2. Figure 1
The urinary creatinine to serum creatinine ratio (UCr/PCr) in the studies in which a loading dose of creatinine was followed by intravenous administration at a constant rate for two hours. Data were collected after 30 minutes of equilibration, and two or three clearance periods were done in each subject. Each value represents one clearance period and each sign a different individual (normals, black symbols; transplant patients, red symbols; kidney donor, blue symbol). The baseline values of the normal subjects are shown as mean ± SD. Maximal UCr/PCr ratios are observed with PCr values between 500 and 700 μmol/L.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

3. Figure 2
Relationship between creatinine clearance (CCr) and glomerular filtration rate (GFR) in the same studies shown in Figure 1. Each value represents one clearance period and each sign a different individual: normals in black, transplant patients in red, and a kidney donor (KD) in blue. CCr/GFR ratios increase as the serum creatinine (PCr) increases to 500 and 700 μmol/L. Further increments in PCr are not associated with higher ratios.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

4. Figure 3
Contribution of tubular secretion to the creatinine clearance in the constant infusion studies. Transplant patients (▪, N = 5) are unable to raise the tubular secreation of creatinine (TSCr) in relationship to the PCr to the levels found in normal individuals (□, N = 12) as the PCr is raised with constant creatinine infusions. The TSCr/PCr ratios decrease with time. Values are mean ± SD. *P < 0.05; **P < 0.01; ***P <
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

5. Figure 4
Percent decrease of PCr after the bolus administration of 88.4mmol creatinine per kg. Time 0 indicates the end of the bolus administration (100%). Normals (□, N = 14), kidney donors (KD; ○, N = 7), transplant patients (▪, N = 11). *P < 0.05 vs. normals.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

6. Figure 5
GFR (A) and CCr (B) in normals (□, N = 14), KDs (○, N = 7), and transplant patients (▪, N = 11) during the tubular stress test. Values are mean ± SD.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

7. Figure 6
TSCr in the tubular stress test. Normals (□, N = 14), KDs (○), and transplant patients (▪, N = 11). (a) P < vs. normals and P < 0,05 vs. KDs. (b and c) P < 0.01 vs. normals and P < 0.05 vs. KDs). Data shown are mean ± SD.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

8. Figure 7
Percent excreted of the creatinine load in normals (□, N = 14), KDs (, N = 7), and transplant patients (▪, N = 11). Error bars indicate SD. ***P < 0.001; **P < 0.01.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions