1. Volume 18, Issue 4, Pages 396-403 (June 2015)
Responder Definition of a Patient-Reported Outcome Instrument for Laryngopharyngeal Reflux Based on the US FDA Guidance 
Han-Chung Lien, MD, MPH, Chen-Chi Wang, MD, Shou-Wu Lee, MD, Jeng-Yuan Hsu, MD, Hong-Zen Yeh, MD, Chung-Wang Ko, MD, Chi-Sen Chang, MD, PhD, Wen-Miin Liang, PhD 
Value in Health 
Volume 18, Issue 4, Pages (June 2015)
DOI: /j.jval
Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

2. Fig. 1
Mean changes in RSI scores from baseline between patients with 50% or more and less than 50% reduction in the primary laryngeal symptom at week 12. (The “I” bars represent standard error.) RSI, Reflux Symptom Index.
Value in Health  , DOI: ( /j.jval )
Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

3. Fig. 2
Illustrative cumulative distribution function shows a distinct difference in cumulative percentage at the RSI score reduction of six points from baseline between patients with 50% or more and less than 50% reduction in the primary laryngeal symptom at week 12. (X-axis, the RSI score change from baseline; Y-axis, cumulative percentage of patients; Sensitivity, cumulative percentage for patients with ≥50% reduction in the primary laryngeal symptom; Specificity, 1 − cumulative percentage for patients with <50% reduction in the primary laryngeal symptom). RSI, Reflux Symptom Index.
Value in Health  , DOI: ( /j.jval )
Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions