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Targeting Aerosol Deposition in Patients With Cystic Fibrosis
Laube Beth L. , PhD, Jashnani Rajkumari , PhD, Dalby Richard N. , PhD, Zeitlin Pamela L. , MD, PhD, FCCP CHEST Volume 118, Issue 4, Pages (October 2000) DOI: /chest Copyright © 2000 The American College of Chest Physicians Terms and Conditions
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Figure 1 I: O ratios after fast and slower inhalations of the two aerosols. The dark bars represent mean values. For the3.68-μm droplets, I: O ratio was unchanged by the two breathing rates. In contrast, I: O ratio was significantly decreased during slowerinspirations of the 1.01-μm droplets, compared to faster inspirations(p = 0.012). CHEST , DOI: ( /chest ) Copyright © 2000 The American College of Chest Physicians Terms and Conditions
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Figure 2 Skew values after fast or slower inhalations of the two aerosols. The dark bars represent mean values. For the3.68-μm droplets, skew values were unchanged by the two inspiratorymaneuvers. In contrast, skew values were significantly reduced afterslower inspirations of the 1.01-μm droplets, compared to the fasterbreathing maneuvers (p = 0.018). CHEST , DOI: ( /chest ) Copyright © 2000 The American College of Chest Physicians Terms and Conditions
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Figure 3 Aerosol deposition fraction within the lungs afterfast or slower inspirations of the two aerosols, expressed as apercentage of the amount of radioactivity available for inhalation. Thedark bars represent mean values. Deposition fraction was significantlyincreased during the slow inspiratory maneuvers compared to fasterinspirations for the 3.68-μm droplets (p = 0.038) and for the1.01-μm droplets (p = 0.051). CHEST , DOI: ( /chest ) Copyright © 2000 The American College of Chest Physicians Terms and Conditions
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