1. Postoperative Refraction and Patient Satisfaction after Bilateral Implantation of Presbyopia-Correcting Intraocular Lenses
Robert Cionni, MD
Financial Disclosure: the author of this e-Poster is a Consultant to Alcon and has received research funding and presentation support from Alcon Research, Ltd.

2. Purpose
To evaluate predictability of refractive outcomes and patient satisfaction after bilateral implantation of presbyopia- correcting intraocular lenses with aspheric apodized diffractive or aspheric and spherical accommodative optics.

3. Methods
Cataract patients with <1 diopter of corneal astigmatism underwent on-label, bilateral implantation of:
ReSTOR IQ +3.0D add IOLs
Crystalens AO IOLs
Crystalens HD IOLs
Refractive enhancements were not permitted before study end
6-month, prospective, randomized, subject- masked study
3 month interim results are presented here
Study conducted at four-centers in the US

4. Methods
Manifest refraction (MR) was measured preoperatively and postoperatively at 1 and 3 months
Patients self-rating of bilateral vision (without glasses) was evaluated using the Cataract TyPE questionnaire*
Rating scale of 0 to 10 (0=best, 10=worst) *
Javitt J, Jacobson G, Schiffman R. Validity and reliability of the Cataract TyPE Spec: an instrument for measuring outcomes of cataract extraction. Am J Ophthalmol. 2003;136:

5. Patient Demographics AGE GENDER N-Value Mean Age in Years (SD)
Age Range
IQ ReSTOR +3.0 D IOL 47
63.4 (9.4)
41 to 81
Crystalens HD IOL 44
64.0 (7.8)
50 to 79
Crystalens AO IOL 41
65.3 (7.5)
50 to 81
Between-treatment p-value: p = 0.56
GENDER
N-Value
Male
Female
IQ ReSTOR +3.0 D IOL 47
40.4%
59.6%
Crystalens HD IOL 44
43.2%
56.8%
Crystalens AO IOL 41
36.6%
63.4%
Between-treatment p-value: p = 0.82

6. Mean Postop Refraction 1-month visit
Postoperative myopia observed among eyes implanted with Crystalens IOLs *
*P<.0001; denotes statistically significant difference between IQ ReSTOR +3 IOL and Crystalens HD & AO IOLs.

7. Mean Postop Refraction 3-month visit
Postoperative myopia observed among eyes implanted with Crystalens IOLs. * IQ
*P<.0001; denotes statistically significant difference between IQ ReSTOR +3 IOL and Crystalens HD & AO IOLs.

8. Predictability of Refraction within ±0.5 D* *
N=74
N=76
N=55
N=53
N=59
N=61
*P=.02; IQ ReSTOR +3 IOL compared with Crystalens HD IOL

9. Self-Rating of Uncorrected Vision
Mean ratings were highest for the apodized diffractive IOL group (+3.0 D),
followed by the aspheric (AO) and the spherical (HD) accommodating IOLS.
Best * *
Better Rating
Worst
*p< 0.001

10. Conclusions
One and three months after bilateral implantation of presbyopia-correcting IOLs, patients had:
more predictable refractive outcomes with aspheric apodized diffractive IOL than with the accommodative aspheric or accommodative spherical IOLs 
greater satisfaction with the aspheric apodized diffractive IOL than with the accommodative aspheric or the accommodative spherical IOLs