1. Metabolic, Humoral, and Inflammatory Factors

2. Gaps Better define underlying etiologies and pathophysiology
More specific nomenclature
Multimodal brain syndrome,
TMF: subsyndromes
Vascular Neuroexecutive Syndrome
Animal models, esp for mood and physical function
Mechanisms by which exercise and physical activity affect mood, cognition and physical function

3. Research Priorities
Expand existing basic, epi, and intervention studies to examine all three domains
Animal models of TMF and methods for studying mood and physical function in animal models
Mechanisms of exercise and physical activity effects

4. Research Opportunities
Effects of function promoting anabolic therapies on cognition and mood in clinical trials
Effects of immune modulation on cognition, mood and physical function
Human intervention trials
Multimodality interventions
High risk groups
Include all three domains as outcomes