1. The Circulatory System

2. The Circulatory System
-pumps and directs blood cells and substances carried in blood to all tissues of the body.

4. Cardiovascular System

5. The CVS is composed of:
Heart- an organ whose function is to pump the blood. Arteries- a series of efferent vessels that become smaller as they branch into the various organs. - carry the blood to the tissues. Capillaries-the smallest blood vessels - site of oxygen and carbon dioxide, nutrient and waste product exchange between blood and tissues. Veins- which result from the convergence of capillaries into a system of larger channels that continue enlarging as they approach the heart, toward which they convey the blood to be pumped again.

6. Heart
The heart is a muscular organ that contracts rhythmically, pumping the blood through the circulatory system
The right and left ventricles pump blood to the lungs and the rest of the body respectively
The right and left atria receive blood from the body and the pulmonary veins respectively.

7. The Heart’s 3 major layers:
The inner endocardium of the endothelium and subendothelial connective tissue.
The myocardium of cardiac muscle.
The epicardium, connective tissue with many adipocytes and covered mesothelium.

8. The endocardium consists of:
The endocardium: consists of a single layer of squamous endothelial cells on a thin layer of loose connective tissue containing elastic and collagen fibers as well as some smooth muscle cells.

9. The Myocardium The thickest layer.
Consist mainly of cardiac muscle with its fibers arranged spirally around each heart chamber

10. The Epicardium
Simple squamous mesothelium supported by a layer of connective tissue containing blood vessels and nerves.
The epicardium is the visceral layer of the pericardium and is covered by the simple squamous-to-cuboidal epithelium (arrows) that also lines the pericardial space. These mesothelial cells secrete a lubricate fluid that prevents friction as the beating heart contacts the parietal pericardium on the other side of the pericardial cavity.

11. Tissues of the vascular wall
Walls of all blood vessels except capillaries contain smooth muscle and connective tissue in addition to the endothelial lining.
The endothelium is a specialized epithelium that acts as a semipermeable barrier between two internal compartments: the blood plasma and the interstitial tissue fluid.

12. Functions of Endothelial cells
Nonthrombogenic surface
Regulate local vascular tone and blood flow
Inflammation and local immune responses
Secrete growth factors

13. The Arterial System
Definition: The arterial system carry the blood from the heart to the capillaries.
According to the size of the arteries there are three types :
Large arteries (Elastic arteries).
Medium arteries (Muscular arteries).
Small arteries (Arterioles).

14. The histological structure of the large arteries (Elastic Arteries)
It is formed of the three basic layers:
The tunica intima: formed of simple squamuse epithelium called the endothelium rest on basement membrane of elastic fibers .
Tunica media: It is thickest layer. Consists of elastic fibers and a series of concentrically arranged, perforated elastic laminae. Between the elastic laminae are smooth muscle cells.
Tunica adventitia (tunica externa): consists principally of type I collagen and elastic fibers and small vessels called vasa vasorum.

15. Large Artery

16. Large Artery

17. The histological structure Medium Artery (Muscular Arteries)
Tunica intima: formed of endothelium separated from the tunica media by the internal elastic layer.
Tunica media: contains up to 40 layers of more prominent smooth muscle cells which are intermingled with a variable number of elastic lamellae. Separated from the adventitia by the external elastic layer.
Tunica adventitia: formed of collagenous fibers support the artery with surrounded structure.

18. Medium Artery (Muscular Arteries)

19. Arterioles
Muscular arteries branch repeatedly into smaller and smaller arteries, until reaching a size with only two or three medial layers of muscle.
Tunica intima: formed of endothelium. The subendothelial layer is very thin, the elastic laminae are absent.
Tunica Media: consists of one or two smooth muscle layers. Arterioles are generally less than 0.5 mm in diameter.
Tunica Adventitia: In both small arteries and arterioles, the tunica adventitia is very thin and inconspicuous.

20. Arterioles

21. The capillaries
Definition: It is an inter connected thin walled vessels through which the material exchange between the blood and the tissue.
The blood reach the capillaries through small arteries called pre capillary and leave it through small venules called post venules.

22. The capillaries
The wall of the capillaries is thin and formed of layer of endothelium of flat cells rest on basement membrane.
Type of capillaries according to the endothelium lining:
Continuous capillaries: there is No opening between the endothelium cells this type formed the most of the body capillaries.
Fenestrated capillaries: in this type there are opening between the endothelium cells. The basal lamina of the fenestrated capillaries is continuous, covering the fenestrae. As in the kidney, the intestine and the endocrine glands.
Discontinuous capillaries: the endothelial cells have large fenestrae and the basal lamina is also discontinuous. As in the liver, spleen, some endocrine organs, and bone marrow

24. Venules
The transition from capillaries to venules occurs gradually. The immediate postcapillary venules are similar structurally to capillaries
Venules converge into larger collecting venules which have more contractile cells.
With greater size the venules become surrounded by recognizable tunica media with two or three smooth muscle layers and are called muscular venules.
A characteristic feature of all venules is the large diameter of the lumen compared to the overall thinness of the wall.

25. Venules

26. Veins
Blood entering veins is under very low pressure and moves toward the heart by contraction of the tunica media and external compressions from surrounding muscles and other organs.
Valves project from the tunica intima to prevent back-flow of blood. Most veins are small or medium veins. The intima usually has a thin subendothelial layer .
The tunicamedia: consists of small bundles of smooth muscle cells intermixed with reticular fibers and a delicate network of elastic fibers.
The collagenous adventitial layer is well-developed.

27. Veins

28. Large Veins Large veins have a well-developed tunica intima.
The tunica media is relatively thin, with few layers of smooth muscle and abundant connective tissue.
The adventitial layer is thickest layer in large veins and frequently contains longitudinal bundles of smooth muscle.
Both the media and adventitia contain elastic fibers, but elastic laminae like those of arteries are Not present.
Most veins have valves, but these are most prominent in large veins.
Valves consist of paired semilunar folds of the tunica intima projecting across part of the lumen.

29. Wall of large vein with valve

30. Summary
Tunica intima, tunica media, and tunica externa (or adventitia)
An artery has a thicker tunica media and relatively narrow lumen.
A vein has a larger lumen and its tunica externa is the thickest layer. The tunica intima of veins is often folded to form valves.
Capillaries have only an endothelium, with NO subendothelial layer or other tunics.

31. Large Artery vs Large vein
Aorta
Vena Cava

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