1. Aim # 55: How can we compare chromosome mutations and gene mutations?
Date: March 6th, 2017-period 5
Aim # 55: How can we compare chromosome mutations and gene mutations?
HW:
Daily Review of Class Notes
Sexual Reproduction Review due Tuesday
Test Friday
Do Now:
Name three GENE mutations and a brief description.
What is nondisjunction?
Define monosomy and trisomy.
What causes Down’s Syndrome?

2. Aim # 55: How can we compare chromosome mutations and gene mutations?
Date: March 6th, 2017-period 1
Aim # 55: How can we compare chromosome mutations and gene mutations?
HW:
Daily Review of Class Notes
Sexual Reproduction Review due Wednesday
Test Thursday
Do Now:
Define the term mutation.
How does a mutation affect the protein product?
Use the terms: bases, amino acids, shape, function

3. Aim #55: How can we compare chromosome mutations & gene mutations?

4. 1) Chromosome Mutation:
Causes a change
in chromosome
number.
Nondisjunction- occurs when homologous
chromosomes or sister chromatids fail to separate
during meiosis.

5. 2) Trisomy Vs Monosomy: Trisomy 21 Monosomy X 3 Copies of a
Chromosome
1 copy of a
homologous pair
Down Syndrome
Turner Syndrome

6. 3) What causes nondisjunction to occur?
No one really knows for sure,
but the older the age of the
mother the greater the
likelihood of having a child
with Down Syndrome.
Trisomy 21

7. 4) Chromosome Damage: Part of a chromosome is repeated.
missing.
Reversing a fragment of the
chromosome.
A fragment of one
chromosome attaches to a
Non homologous chromosome.

8. II. Gene Mutations:
Is due to a change in the nucleotide sequence of DNA.
They can involve large regions of a chromosome or
just a single nucleotide pair.

9. 2) Genetic Diseases caused by gene mutations:
Cystic Fibrosis
Faulty gene produces a
defective protein that does not allow for the proper
removal of mucous lining the cells of the lung and GI
tract.

10. 3) Gene Mutations: Tay-Sachs Disease
Faulty gene produces a defective enzyme
which cannot help remove fat from nerve cells.

11. 4) Sickle-Cell Anemia:
One base is substituted for another and this causes
the production of a distorted hemoglobin molecule
(protein) which cannot function properly.

12. 5) What do these three gene mutations have in common?
They all affect the shape of proteins!! If we change
the shape of proteins (enzymes) they will not
function properly and this will affect our phenotype.

13. Amoeba Sisters Mutations