2. The global medical imaging reagents market was valued at $10
The global medical imaging reagents market was valued at $10.3 billion in 2012 and is expected to reach an estimated value of $18.5 billion in 2019.

3. What we do: Seeing the Invisible
Optical probe
(IV)
Dye
Linker
Recognition
Element
Diagnostic and
Pre-operative planning
Charge
Quenching/FRET
Wavelength
Size
Specificity
Stability
Enzymes
Receptors
Membrane
Affinity-based
Dye On
Dye On
In-vivo
Surgical guidance
Ion-Channel
Receptors
Membrane
Activity-based
Dye On
Recognition
Element
Dye
Off
Recognition
Element
Ex-vivo
Surgical guidance
Substrate-cleavage
Tissue sample
Protease
Hydrolase
Transpeptidase
Aminopeptidase
Dye On
Optical probe
topical administration

4. Who we are?

6. EMI-137
Value in CRC SCREENING

9. EMI-137 Reduction in Morbidity/Mortality: Colonoscopy Prevent Carcinomas
10% ⅓
96%
adenomas progress to colorectal cancer
Early detection & removal of polyps eliminates the possibility they become cancerous.
of adults develop ≥ 1 polyps by
age 50, this increases with age
of colorectal cancers develop
from adenomatous polyps
over a period of years

10. Standard Colonoscopy Misses Disease
22% miss rate, increases as lesions get smaller. Major reason for CRC in screening population is missed lesions (60%), Poor resection accounts for 20%.
An improved detection rate (25%), and lesion classification has been demonstrated

11. Value in Fluorescent ImagE guided Surgery
EMI-137
Value in Fluorescent ImagE guided Surgery

12. C-Met: Broad expression in Large range of Tumours
Cancer type
c-Met Expression
Poor prognosis
Application
Optical System Type
Bladder 4
Diagnosis & Resection
FCFM*, Laproscope
Breast
Surgical Guidance
Open Surgical
Cervical
Open Surgical, Laparoscope
Cholangiocarcinoma
FCFM, Surgical
Colorectal
FCFM, Endoscope, Open Surgical
Endometrial 6
FCFM
Esophageal
FCFM, Endoscope, Laparoscope
Gastric
H&N
Kidney
Liver
Lung
Melanoma
Nasopharyngeal
Ovarian
Pancreatic/Gall Bladder
FCFM, Laparoscope, Open Surgical
Prostate
Open Surgery , Laparoscope
Thyroid
Open Surgery 10

14. Pre-operative planning
Clinical Studies
Agent
Indication
Report out
Funding & Partners
CRC Lesion Detection
PhIIB in 50+ at risk of CRC patient (1Q-17)
EMI-137
Single Pulmonary Nodule
Exploratory Clinical study in 20 subjects (1Q-17)
EMI-200
Lung Inflammation
Phase IIa study in 100 ICU patients (4Q-16)
EMI-350
Lung Infection
Exploratory Clinical study in 10 ICU patients (3-4Q-16)
Diagnostic and
Pre-operative planning
EMI-400
Lung Fibrosis
Exploratory Clinical study 10 Lung Fibrosis patients (1Q-17)
EMI-137
Investigator Initiated Studies
Exploratory Clinical Studies in cancer surgery patients (4Q-16)
EMI-350
Investigator Initiated Studies
Exploratory Clinical Studies in infection of hip prosthesis (2Q-17)
In-vivo
Surgical guidance