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Imaging the Transformation of Ipsilateral Internal Capsule Following Focal Cerebral Ischemia in Rat by Diffusion Kurtosis Imaging Xiao-xue Zhang, Le-kang Yin, Xiao-zhu Hao, Jia-qi Tian, Chan-chan Li, Xiao-yuan Feng, Yan-mei Yang Journal of Stroke and Cerebrovascular Diseases Volume 26, Issue 1, Pages (January 2017) DOI: /j.jstrokecerebrovasdis Copyright © 2017 National Stroke Association Terms and Conditions
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Figure 1 Experimental procedure. The left middle cerebral artery was occluded for 60 minutes for all the rats. MRI data were acquired to check occlusion and obtained DKI metrics of the left hemisphere on day 1, day 3, day 7, day 14, and day 28. Functional examination was repetitively performed at the same time points before MRI. Abbreviations: DKI, diffusion kurtosis imaging; MRI, magnetic resonance imaging. Journal of Stroke and Cerebrovascular Diseases , 42-48DOI: ( /j.jstrokecerebrovasdis ) Copyright © 2017 National Stroke Association Terms and Conditions
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Figure 2 Neurological function score (mean ± SD) as a function of time after stroke. **P < .01 versus day 1. ***P < .001 versus day 1. Abbreviation: SD, standard deviation. Journal of Stroke and Cerebrovascular Diseases , 42-48DOI: ( /j.jstrokecerebrovasdis ) Copyright © 2017 National Stroke Association Terms and Conditions
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Figure 3 FA, MD, Da, Dr, MK, Ka, and Kr maps of a rat subjected to transient MCAO obtained at 1 day, 3 days, 7 days, 14 days, and 28 days after occlusion. The MCAO duration was 60 minutes. The black arrow shows the position of IC. Abbreviations: Da, axial diffusivity; Dr, radial diffusivity; IC, internal capsule; MCAO, middle cerebral artery occlusion. Journal of Stroke and Cerebrovascular Diseases , 42-48DOI: ( /j.jstrokecerebrovasdis ) Copyright © 2017 National Stroke Association Terms and Conditions
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Figure 4 Time course of the relative parameters (rFA, rMD, rDa, rDr, rMK, rKa, and rKr) in the IC of the MCAO. Statistically significant differences between time points are shown. *P < .05, **P < .01, ***P < .001. Abbreviations: IC, internal capsule; MCAO, middle cerebral artery occlusion; rDa, relative axial diffusivity; rDr, relative radial diffusivity; rFA, relative fractional anisotropy; rKa, relative axial diffusional kurtosis; rKr, relative radial diffusional kurtosis; rMD, relative mean diffusivity; rMK, relative mean diffusional kurtosis. Journal of Stroke and Cerebrovascular Diseases , 42-48DOI: ( /j.jstrokecerebrovasdis ) Copyright © 2017 National Stroke Association Terms and Conditions
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Figure 5 Time course of the relative parameters (rMD and rMK, rKa and rKr) in the IC of MCAO. Statistically significant differences between time points are shown. *P < .05 right versus left, **P < .01 right versus left, ***P < .001 right versus left. Abbreviations: IC, internal capsule; MCAO, middle cerebral artery occlusion; rKa, relative axial diffusional kurtosis; rKr, relative radial diffusional kurtosis; rMD, relative mean diffusivity; rMK, relative mean diffusional kurtosis. Journal of Stroke and Cerebrovascular Diseases , 42-48DOI: ( /j.jstrokecerebrovasdis ) Copyright © 2017 National Stroke Association Terms and Conditions
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