1. Proopiomelanocortin (POMC) processing
Proopiomelanocortin (POMC) processing. Corticotropin-releasing hormone stimulates the production, release, and processing of POMC, a preprohormone synthesized in the anterior pituitary. POMC is post-translationally cleaved to adrenocorticotropic hormone (ACTH); β-endorphin, an endogenous opioid peptide; and α-, β-, and γ-melanocyte-stimulating hormones (MSHs). The cellular effects of these peptides are mediated via melanocortin (ACTH and MSH) or opiate (β-endorphin) receptors. LPH, β-lipotropin.
Source: Chapter 3. Anterior Pituitary Gland, Endocrine Physiology, 4e
Citation: Molina PE. Endocrine Physiology, 4e; 2013 Available at: Accessed: October 19, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved