1. Presented by, G.Hemalatha K.Chandar K.Nagaraju P.Kamaldas V.Kalpana
vanillin
Presented by,
G.Hemalatha
K.Chandar
K.Nagaraju
P.Kamaldas
V.Kalpana

2. introduction
Vanillin is a herbal drug obtained from the dried pods of Vanilla planifolia
synonym:vanilla beans, vanilla pods
Family: Orchidaceae

3. Chemical structure Chemically vanillin is,
4-hydroxy 3-methoxy benzaldehyde.

4. Aim of the work
To synthesise the semisynthetic derivatives of vanillin which are used in our daily biological activities.

5. Objectives of the work
To optimize the biological activity of the compounds selected in the study.
The compounds selected for the study are volatile in nature, formation of non volatile derivative with a better activity avoids the wastage through vaporization and also increases the potency.
The compounds to be synthesized in this study are very simple derivatives and follow one or two step reactions, thus there is very less chance for the degradation of the starting compound.
The compounds synthesized in this study will be subjected for TLC, physical and spectral analysis in order to identify purity, and to interpret the structure of the derivatives synthesized.

6. plan of the work
Based on this concept the present work was designed to synthesize semisynthetic derivatives of some commonly used phytoconstituent’s. In the present study semisynthetic derivatives of vanilla are synthesized. These derivatives are chosen due to their wide pharmacological activity and are used in our day to day life.

7. Experimental work
procedure
Take about 1 gm of hydrazine sulphate, 0.8 gm of sodium acetate in little quantity of distilled water and shaken well, added 2 gm of vanillin and shaken well till it becomes clear solution, if necessary add ethanol to dissolve the contents.

8. The thoroughly dried substance is to be subjected for analytical work
In this experiment vanillin is treated with semicarbazide in the presence of sodium acetate.
The resulted product is Hydrazine methylidene vanillin

9. The entire mixture warmed on water bath continuously for about 1 hour under reflux and allowed to cool to get the compound hydrazine di methyl vanillin, which is filtered and subjected for recrystallization with suitable solvent like alcohol.

11. uses The uses of the newly generated product are Analgesic
Antibacterial
Anti helmenthic

12. Uses of vanillin
Flavouring agent
Perfumary
Masking agent

13. conclusion
The literature survey reveals that some activities like Antibacterial, Antioxidant & analgesic activities etc… which are found weak, to increase its biological activity,a modification of functional groups in the structure/ modification of structure, may increase their pharmacological actions.

14. bibliography
Satyajit D Sarker, Lutfun Nahar, “Chemistry For Pharmacy students General , Organic and natural Product Chemistry”, Nat prod chem, John Wiley & Sons Ltd, chapter 6,pg no , 2004.
Dr. C. K. Kokate, A. P. Purohit, S. B. Gokhale, “Pharmacognosy”,Nirali prakashan ; Pune, thirty eighth edition, p.no:1-6,2007
Newman DJ, Cragg GM. “Natural products as sources of new drugs over the last 25 years” J Nat Prod, 70, (2007).
Dan Bensky, Steven Clavey, Erich Stoger, and Andrew Gamble “Chinese Herbal Medicine: Materia Medica” Third Edition 2004.