1. REducing Deaths due to OXidative Stress
The REDOXS© Study
REducing Deaths due to OXidative Stress
Improvement Targets
Promotility Agents & Small Bowel Feedings
REDOXS patients who receive < 80% of prescribed
study supplements, a median of 51% received motility
agents and 26% had small bowel feedings.
The Canadian CPGs recommend patients who
experience feed intolerance (high gastric residuals,
emesis), the use of a promotility agent is
recommended. In units where obtaining small bowel
access is feasible, this should be used routinely.
Volumes of REDOXS© Study Supplements
Administered
It is important to ensure that the full volume of study
supplements is administered each day. If there are
interruptions, remember the rate can be adjusted to
make of for these lost volumes up to a total of
doubling the rate for 12 hours.
Site Specific
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High Performance
Timely initiation of REDOXS© Study Supplements
Our ICU is doing an excellent job with respect to initiating REDOXS© study supplements within 2 hours of randomization
Early Enteral Nutrition
REDOXS© sites have performed well, with a median time of 20 hours for initiation of enteral nutrition! The Canadian Nutrition CPGs recommend that enteral nutrition be initiated within hours of admission to ICU.
Site Specific
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Data derived from the first 600 patients randomized to the REDOXS © Study.
Study Sponsor: Dr Daren K Heyland
Clinical Evaluation Research Unit, Queen’s University
Kingston ON, Canada