1. Corresponding Author (Email): mariam12@gmail.com
Treatment of breast ductal carcinoma in situ (DCIS) as a rare entity in an unscreened population in a developing country Mariam Baig, Sadaf Batool, Sana Amir Akbar, Mohammad Zulqarnain Chaudhry, Amina Iqbal Khan, Muhammad Asad Parvaiz Department of Breast Surgery, Shaukat Khanum Memorial Cancer Hospital & Research Center, Pakistan
INTRODUCTION
The incidence of ductal carcinoma in situ (DCIS) in breast has been reported very low in Pakistan due to absence of population based screening programme.
OBJECTIVE
Evaluate the surgical treatment options for DCIS, in a developing country so that best surgical option can be proposed for future management.
RESULTS
Median Age: 48 years
Breast conserving surgery (BCS): 42%
Mastectomy: 58%
Median tumour size: 12.5mm in Mastectomy group and 5mm in BCS group
Invasive component: 0.06% BCS group and 0.14% mastectomy group.
High nuclear grade DCIS: BCS group 0.32%) 0.4% in mastectomy group
Overall Survival: 96%
METHODS
Study Period: January 2000 – December 2011
Diagnosed on core or excisional biopsy
Evaluated for tumour size, resection margins, nodal disease, receptor status and nuclear grade
Disease free survival and overall survival measured
Breast Cancer Patients: 8269
DCIS Presented at SKMCH & RC: 94
DCIS Treated at SKMCH & RC: 73
CONCLUSION
DCIS is mainly identified in symptomatic patients
Relatively smaller size DCIS even with high nuclear grade, can be successfully treated with BCS. Mastectomy remains the standard of choice for larger size DCIS
REFRENCES
Clinicopathologic Profile of Breast Cancer Patients in Pakistan: Ten Years Data of a Local Cancer Hospital Samina Khokher, Muhammad Usman Qureshi , Masooma Riaz , Naseem Akhtar , Afaf Saleem. Asian Pacific J Cancer Prev, 13,
Controversies in the Treatment of Ductal Carcinoma in Situ Andrea V. Barrio and Kimberly J. Van Zee Annu. Rev. Med :197–2
Shaukat Khanum Memorial Cancer Hospital & Research Center, 7A, Block R3, Johar Town, Lahore, Pakistan.
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