1. Blood & tissue protozoa of humans
Trypanosoma
Leishmania
Malaria

2. Trypanosoma Species pathogenic to man: T gambiense T rhodesiense
T cruzi

3. Morphology
Fusiform, Nucleus in the middle, posterior kinetoplast , anterior free flagellum

6. Movement
Reproduction
Nourishment( blood, lymph , C.S.F)
Culture: NNN medium.

7. Life cycle
Ulternate existence in vertebrate &invertebrate host.

8. T. gambiense( mid African sleeping sickness)
Vertebrate host : Man
Invertebrate host : Tse Tse fly Glossina

10. Epidemiology West & central Africa
Transmission : bite of tse tse fly ( after cyclic development of parasite).
Mechanical : During epidemics.

11. Pathology & symptomatology:
Acute stage : blood & lymph
Chronic stage : C.S.F.
Incubation period:

12. Acute stage Chronic stage

14. Trypanosoma rhodesiense ( East African sleeping sickness)
Life cycle:
Morphology:
Pathogenicity : More rapid ,severe, fatal than gambian Tryp.

15. Trypanosoma cruzi ( American tryponosomiasis)
Morphology:
Life cycle:
Vertebrate host (human , domesticated & wild animals)
Invertebrate host: Reduviid bugs .

19. Epidemiology Pathology & symptoms: In the blood : Trypanosomal form
In the cells : Amastigote form.
Invade skeletal , cardiac & other muscle fibers

20. Symptoms
The most common are cardiac & GIT symptoms.

21. Diagnosis
Treatment: Nitrofuran.