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Published byLora Vivian Cain Modified over 6 years ago
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Simulating Low-Frequency Sonic Pulsations to Achieve Thrombolysis
Thank you, pleasure to be, from weldon school of BME, start. Joseph C Muskat SURF 2015
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Heart Attacks
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Existing Approaches Clot-busting drugs
Mechanical devices (catheters, lasers)
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Device Concept
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Biomechanical Model for Simulating Sonic Pulsations
2D finite element model, cylindrical coordinates |||| Fewest number of nodes to maintain mechanical integrity x x
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Validation E(numerical)= 755 Pa E(input) = 750 Pa Axial constraints
Radial constraints
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Sonic Vibrations Produce Resonance
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Resonance
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Sonic Vibrations Produce Resonance
Greatest oscillation at natural frequency Put a peak graph in top right.
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Fracture
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Comparison with ANSYS MATLAB deviates <2.5% Radius MATLAB ANSYS
1.3 mm 140 Hz Hz 2.0 mm 73 Hz Hz 2.5 mm 66 Hz 68.6 Hz MATLAB deviates <2.5%
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Conclusions Small pressure pulsations can cause resonance in idealized blood clot models. Clot fragmentation can occur at these resonant frequencies. Purpose-built finite element models compare well to advanced CAD packages.
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Future Work Atherosclerotic plaque Non-catheter, non-invasive
Distal fragmentation
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Acknowledgements Charles F. Babbs, MD, PhD Matthew C. Pharris, GTA
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