1. Institute of Biomedical & Genetic Engineering (IBGE)
Nafees Ahmad, PhD (Germany)
Principle Scientific Officer (PSO)
Group Head: Functional Genomics
24-Mauve area, G-9/1, Islamabad

2. Molecular Diagnostics
Scope of IBGE
Biomedical Research
Services
Cancer
Molecular Diagnostics
HBV
HCV
HLA
Forensic
Thalassemia
Neurodegenerative
Neuropsychiatric
Carrier Screening
Skin (XP, Ichthyosis)
BCR-ABL
FLT3
JAK2
EGFR
Genetic Counseling
Inherited Disorders
For details visit:

3. Scope of Functional genomics

4. Research Projects
Project 1: Genetic and Molecular basis of Neurodegenerative movement disorders (IBGE-RGGD-FG-QP-01)
Project 2: Genetic and Molecular basis of Neuropsychiatric disorders (IBGE-RGGD-FG-QP-02)
Project 3: Targeted Cancer therapeutics (IBGE-RGGD-FG-QP-03)
Project 4: Cancer Diagnostic and Prognostic Biomarkers
(IBGE-RGGD-FG-QP-04)

5. Familial Adenomatous Polyposis (FAP)
An autosomal dominant inherited condition ? ?

6. Genetics of (FAP) Mutation in
APC gene – a key tumor suppressor gene (80-90%)
MUTYH gene – a DNA repair gene (10-20%)
Chromosome 5
Chromosome 1
MUTYH
(1p34.1)
APC
(5q22.2)

7. Mutation Cluster region of APC gene
Exon 15

8. Colorectal Cancer
Nature Reviews Cancer 3, (August 2003)