1. Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology
Dermatology 2016;232: DOI: /
Fig. 1. Pathogen-derived signals activate the NLRP3 inflammasome, activating caspase-1 and stimulating the formation of IL-1β from its precursor. In cryopyrin-associated periodic syndrome, a mutated domain of NLRP3 leads to autoactivation of the same inflammatory cascade.
© 2016 S. Karger AG, Basel

2. Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology
Dermatology 2016;232: DOI: /
Fig. 2. Urticarial eruption seen in CAPS.
© 2016 S. Karger AG, Basel