1. Day Date Subject To be read prior to this class period:
M 1/ no class - Snow Day!
W 1/16 Evolution: Unity and Diversity Chapter 1
M 1/21 no class – Rev. Martin Luther King, Jr. Day
W 1/23 Water and the Chemical Environment Chapter 2 (except pp30-35)
M 1/28 Quiz #1 on Ch. 1 and parts of Ch. 2 and related lectures/handouts
(no make ups for missed quiz)
Cell Membranes Chapter 6
W 1/30 Macromolecules Chapter 3 (except pp63-69)
M 2/4 Macromolecules
W 2/6 Quiz #2 on Ch. 3 and 6 and related lectures/handouts
The Cell Chapter 7
M 2/11 Bioenergetics
W 2/13 Cell Respiration Chapter 9
M 2/18 no class - Winter Break
W 2/20 no class - Winter Break
M 2/25 EXAM I Chapters 1, 6,7, parts of 2, 3

14. Aquaporin protein makes a water channel through the cell
(plasma) membrane.

16. Chapter 3 is about protein structure. The example will we use
is the protein Aquaporin.
In Chapter 3, the material on pages is not really covered
until after the first test. That means you need to read it now but
you don’t need to study it until after the first test. Also, I will
talk about this material in class but not until after the first test.
Aquaporin is a protein that floats in the cell membrane.
The function of aquaporin is to form a channel (hole, pore)
through the membrane that allows water to passively diffuse
across the cell membrane. In other words, aquaporin’s job
is to allow the rate of osmosis to increase.

19. Aquaporin is a very selective filter for water and
it is also very fast. A membrane 4” x 4” with
embedded aquaporins could filter 1 gallon of
pure water in just 30 seconds.

20. Aquaporin creates a channel through the cell membrane that only
lets H O
through. 2

23. Major Sites of Expression and Function of Human Aquaporin
Aquaporin-0 Eye: lens fiber cells Fluid balance within the lens
Aquaporin-1 Red blood cells Osmotic protection
Kidney: proximal tubule Concentration of urine
Eye: ciliary epithelium Production of aqueous humor
Brain: choriod plexus Production of cerebrospinal fluid
Lung: alveolar epithelial cells Alveolar hydration state
Aquaporin-2 Kidney: collecting ducts Mediates antidiuretic hormone activity
Aquaporin-3 Kidney: collecting ducts Reabsorbtion of water into blood
Trachea: epithelial cells Secretion of water into trachea
Aquaporin-4 Kidney: collecting ducts Reabsorbtion of water
Brain: ependymal cells CSF fluid balance
Brain: hypothalamus Osmosensing function?
Lung: bronchial epithelium Bronchial fluid secretion
Aquaporin-5 Salivary glands Production of saliva
Lacrimal glands Production of tears
Aquaporin-6 Kidney Very low water permiability; function?
Aquaporin-7 Testis and sperm
Aquaporin-8 Testis, pancreas, liver, others
Aquaporin-9 Leukocytes

28. Aquaporin protein makes a water channel through the cell
(plasma) membrane.