1. Sandra W. Jacobson, Christopher D. Molteno,
NIAAA Collaborative Initiative on Fetal Alcohol Spectrum Disorders Identification of FASD in South African Children: 5-Year Follow-up Study
Sandra W. Jacobson, Christopher D. Molteno,
Denis L. Viljoen, Joseph L. Jacobson

2. Cross-Project Integration
Dysmorphology and growth assessments
Children examined by Nat Khaole using Dysmorphology Core checklist
Clinic with Gene Hoyme and Luther Robinson in Sept/Oct 2005 in Cape Town
3-D camera study
With Elizabeth Moore in Sept/Oct 2005 in Cape Town
Neurobehavioral battery (58 children tested to date)
Leiter, pegboard, VMI, handedness
Number processing and executive function tasks
Eyeblink conditioning--integrates with animal studies

3. Additional Related Projects
Eyeblink conditioning—infant pilot study
ADH1B polymorphisms—bloods collected on first 58 mothers and children seen to date
fMRI pilot study

4. fMRI Study in Cape Town
Received grants from NIH/Fogarty International Research Collaboration Award (FIRCA), , and Wayne State University to train and set up first fMRI study in Cape Town
Brought UCT physicist to U.S. for fMRI training
Set up fMRI and mock scanner in Groote Schuur Hospital and ran 1 adult and 6 children under supervision of U.S. collaborator who came with us to Cape Town
Screened 40 children (older siblings of children in our CIFASD cohort) for FASD to serve as pilot subjects and matched controls
Tested first 5 of 40 children in this pilot study in preparation for applying for NIH grant to test children in our CIFASD cohort at age 8 years

5. Recent Publications/Presentations
Carter, R.C., Jacobson, S.W., Molteno, C.D., Viljoen, D., Chiodo, L.M., & Jacobson, J.L. (in press). Effects of prenatal alcohol exposure on infant visual acuity. The Journal of Pediatrics. Selected by journal editors for press release.
Bearer, C.F., Jacobson, J.L., Jacobson, S.W., Barr, D., Croxford, J., Molteno, C.D., Marais, A.S., Chiodo, L.M., Cwik, A.S., & Viljoen, D.L. (2003). Validation of a new biomarker of fetal exposure to alcohol. Journal of Pediatrics, 143,
Jacobson, S.W., Stanton, M.E., Hay, A.M., Burden, M.J., Fuller, D.S., Molteno, C.D., Viljoen, D.L., & Jacobson, J.L. (2005). Impaired short delay eyeblink conditioning in children with FAS: Preliminary findings. Alcoholism: Clinical and Experimental Research, 29, 233.
Croxford, J., Jacobson, J.L., Jacobson, S.W., Marais, A.S., Molteno, C.D., & Viljoen, D.L. (2005). Estimated peak blood alcohol concentration as an indicator of fetal alcohol risk. Alcoholism: Clinical and Experimental Research, 29, 228.