1. CopiOs® Bone Void Filler
CopiOs Bone Void Filler is a synthetic bone graft substitute that creates an environment conducive to bone growth through its unique DICAL mineral component and its 3D collagen scaffold.
Composition: CaHPO4 (DICAL)
Optimal pH Level for Bone Healing
Abundance of Localized Soluble Mineral Ions
Osteoconductive Scaffold

2. Bone Formation (Osteogenesis) Triangle

3. CopiOs Composition – pH Level
Optimal pH for Bone Healing
Moderately acidic pH level promotes solubility of OI growth factors (5.5pH – 5.8pH)
More soluble BMPs may remain available for bone healing processes in the early stages of bone growth

4. CopiOs Composition – Mineral Ions
Abundance of Localized Soluble Mineral Ions Promotes Bone Formation
DICAL provides significantly more Ca & PO4 ions at equilibrium than either ß-TCP or HA

5. CopiOs – Osteoconductive Properties
Osteoconductive Scaffolds Provide Key Role in Bone Regeneration
3D collagen scaffold sponge resembles human cancellous bone and is 93% porous with interconnecting, multi-directional pores
Sponge carrier wicks seven times its weight in autologous blood or bone marrow
These osteoconductive attributes allow cellular attachment, nutrient and oxygen infiltration, and vascularization
Microscopic view of collagen in CopiOs Sponge (200x)
Microscopic view of collagen in CopiOs Paste (100x)